مقايسه تأثير MnO2-NP ها و MnO2-MP ها بر کمپلکس هاي ميتوکندري در ارگان هاي مختلف

اشرفی حافظ, اصغر and ناصر زاده, پروانه and مرتضویان, امیرمحمد and مهروی, بیتا and اشتری, خدیجه and صیدی, عنایت اله and سلیمی, احمد (1397) مقايسه تأثير MnO2-NP ها و MnO2-MP ها بر کمپلکس هاي ميتوکندري در ارگان هاي مختلف. Toxicology Mechanisms and Methods ــ online . شاپا 1537-6516

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Official URL: https://www.tandfonline.com/doi/full/10.1080/15376...


Comparison of the Effects of MnO2-NPs and MnO2-MPs on Mitochondrial complexes in Different Organs

English Abstract

Today, nanoparticles (NPs) have been widely used in various fields. Manganese oxide nanoparticles have attracted a lot of attention due to many applications. One of the major concerns regarding the widespread use of various NPs is the exposure and accumulation in human organs and finally toxicity. The generation of reactive oxygen species (ROS) by mitochondria is one of the most important mechanisms of toxicity suggested by published studies induced by other NPs. However, limited studies have been conducted on the mechanism of toxicity of MnO2-NPs and MnO2-microparticles (MnO2-MPs). In this study, we compared the accumulation of MnO2-NPs and MnO2-MPs in different tissues and evaluated their effects on mitochondrial complexes in isolated mitochondria. Our results showed that intravascular (iv) administration of the MnO2-NPs in the same dose compared to the MnO2-MPs resulted in more accumulation in the C57 mouse female tissues. The effect of MnO2-NPs and MnO2-MPs in mitochondria showed that complexes I and III play an important role in increasing ROS generation and this effect is related to type of tissue. Also, our results showed that exposure to MnO2-NPs and MnO2-MPs reduced the activity of mitochondrial complexes II and IV. Our results suggest that the toxicity of the MnO2-NPs is higher than that of the MnO2-MPs and can lead to the depletion of antioxidant status, likely induction of apoptosis, cancer, and neurodegenerative disease.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :اصغر اشرفی حافظ
نویسنده مسئول :عنایت اله صیدی
نویسنده مسئول :احمد سلیمی
Additional Information:Impact Factor(2017) 1.994 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, EMBASE, BIOBASE, Biological Abstracts, EMBIOLOGY پایایان نامه
کلیدواژه ها (انگلیسی):MnO2-NPs, MnO2-MPs, ROS, Mitochondrial complexes, Toxicity, Mechanism
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
School of Pharmacy > Department of Pharmacology
ID Code:10881
Deposited By: دکتر احمد سلیمی
Deposited On:29 Aug 1397 11:07
Last Modified:29 Aug 1397 11:07

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