اثرات ضد التهابی ویتامین D3 بر بیماران مبتلا به مولتیپل اسکلروزیس

هاشمی, رضا and مرشدی, محمد and اصغری جعفرآبادی, محمد and الطافی, داور and حسینی اصل, سید سعید and عارف حسینی, رفیع (1397) اثرات ضد التهابی ویتامین D3 بر بیماران مبتلا به مولتیپل اسکلروزیس. Neurology: Genetics ــ 4 (6). pp. 1-9. شاپا 2376-7839

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Anti-inflammatory effects of dietary vitamin D3 in patients with multiple sclerosis

English Abstract

Objective To assess the effects of dietary vitamin D3 on proinflammatory (interleukin-17A [IL-17A] and IL-6) and anti-inflammatory (IL-10) cytokines. Methods Our study was conducted on 75 participants who were divided into 3 groups: multiple sclerosis participants (MSPs, n = 25), first-degree relative participants (FDRPs, n = 25), and healthy participants (HPs, n = 25). All groups received 50,000 IU vitamin D3/wk for 8 weeks. Serum 25-(OH) vitamin D3 levels and messenger RNA (mRNA) expression levels of ILs were determined using electrochemiluminescence assay and real-time PCR, respectively. Results Vitamin D3 affected the levels of IL-17A, IL-10, and IL-6 among the 3 groups (p < 0.001 for all). Levels of IL-17A (MSPs: fold change [FC] = 5.9, p = 0.014; FDRPs: FC = 5.2, p = 0.006; HPs: FC = 4.2, p = 0.012) and IL-6 (MSPs: FC = 5.6, p = 0.003; FDRPs: FC = 5.5, p = 0.002; HPs: FC = 5.1, p < 0.001) were downregulated after vitamin D3 treatment. In addition, levels of IL-10 (MSPs: FC = 6.2, p = 0.005; FDRPs: FC = 4.6, p < 0.001; HPs: FC = 5.2, p < 0.001) were upregulated after 8 weeks. Conclusions Although supplementation with vitamin D3 reduced the mRNA expression levels of IL-17A and IL-6, it increased the mRNA expression level of IL-10 in all groups. However, these effects were more considerable in the MSP group than in the other groups. Of interest, in a deficiency state of serum vitamin D3, IL-17A expression had a positive feedback effect on the expression of IL-6. Conversely, in the sufficient state, IL-10 expression had a negative feedback effect on the expression of IL-17A and IL-6.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :رضا هاشمی
نویسنده :داور الطافی
نویسنده :سید سعید حسینی اصل
نویسنده مسئول :رفیع عارف حسینی
Additional Information:Indexed in: ESCI, Pubmed/PMC, Scopus, EMBASE, Google Scholar, DOAJ
Subjects:WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Genetics
ID Code:10904
Deposited By: Dr S Saied Hosseini-Asl
Deposited On:30 Aug 1397 10:25
Last Modified:30 Aug 1397 10:26

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