title

میزان بقای سرطان های معده و مری در استان اردبیل، واقع در شمال غربی ایران

صمدی, فاطمه and بابایی, مسعود and یزدانبد, عباس and فلاح, مهدی and نورایی, مهدی and نصراله زاده, داریوش and سجادی, علیرضا and درخشان, محمدحسین and شکوهی گوگانی, بهروز and فولادی, رباب and ملک زاده, رضا (1385) میزان بقای سرطان های معده و مری در استان اردبیل، واقع در شمال غربی ایران. Archives of Iranian Medicine ــ 10 (1). pp. 32-37. شاپا 1029-2977

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Title

Survival rate of gastric and esophageal cancers in Ardabil Province, North-West of Iran

English Abstract

Background: Upper gastrointestinal cancer is the most common cancer in Ardabil Province, North-West of Iran, accounting for more than 50% of all cancer deaths in this area. We conducted this study to determine the present survival rate of patients with esophageal and gastric cancers before launching interventional studies. Methods: A prospective follow-up study of 420 biopsy-proven patients (127 females, mean age: 64) with upper gastrointestinal cancer (141 esophageal and 279 stomach cancers) who were initially diagnosed in Aras Clinic, the main gastrointestinal referral center of Ardabil Province, from 2000 through 2004, was performed with collection of data on demographics, tumor characteristics, pathologic stage, treatment methods, complications, survival time, etc. Data were gathered through direct interview with patients or their families in 303 cases and evaluation of death certificates,in 55 patients. Follow-up was from cancer diagnosis until death, or Immigration. Survival according to stage of disease, Lauren tumor type, tumor location, surgery, and adjuvant chemotherapy was analyzed, and results were compared with those of western series. Results: Sixty-two cases were lost to follow-up. The one- and five-year survival rates in the patients with upper gastrointestinal cancer in Ardabil Province were 40.5%, and 0.8%, respectively. In the univariate analysis, men had a slightly lower survival rate than women (P = 0.21) and patients with esophageal cancer had a longer survival rate compared to stomach cancer patients (P = 0.15). Patients who had undergone surgery (P < 0.001) and/or chemotherapy (P < 0.001) survived longer than those without such treatments. Tumor morphology, age at diagnosis, radiotherapy, alcohol, and opium consumption did not show any significant effects on the survival rate of patients. In multivariate analysis, only smoking was remained as an independent factor for stomach cancer (P = 0.04) while in esophageal cancer, surgery and grade of differentiation were significant predictors of survival. Conclusion: Survival rate of stomach and esophagus cancer cases in Ardabil Is relatively low. Intervention for early detection and therapy is necessary to increase survival.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :فاطمه صمدی
نویسنده مسئول :رضا ملک زاده
Additional Information:cited By (since 1996) 4 Indexed in: 1- PubMed/MEDLINE, ISI Web of Science, 2-EMBASE, SCOPUS, 3-CINHAL, PASCAL, CSA, 4-SID
کلیدواژه ها (انگلیسی):antineoplastic agent; opiate, adjuvant therapy; adult; aged; alcohol consumption; article; cancer grading; cancer pain; cancer radiotherapy; cancer staging; cancer survival; cigarette smoking; controlled study; death certificate; demography; drug use; early diagnosis; esophagus biopsy; esophagus cancer; esophagus surgery; female; follow up; histopathology; human; immigration; interview; Iran; major clinical study; male; multivariate analysis; patient care; prediction; sex difference; stomach biopsy; stomach cancer; stomach surgery; survival rate; tumor differentiation; tumor localization; tumor volume; univariate analysis, Adult; Aged; Aged, 80 and over; Biopsy; Esophageal Neoplasms; Female; Follow-Up Studies; Humans; Iran; Male; Middle Aged; Neoplasm Staging; Prognosis; Prospective Studies; Rural Population; Sex Distribution; Stomach Neoplasms; Survival Rate
Subjects:WI Digestive System
QZ Pathology
Divisions:Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
Faculty of Medicine > Department of Basic Sciences > Department of Pathology
ID Code:1092
Deposited By: MS Soghra Golmaghani
Deposited On:11 Mar 1389 02:25
Last Modified:10 Jul 1393 07:34

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