تاثیر فلوکستین بر کیفیت زندگی بیماران سرطانی

پیرزاده, اصغر and محمدی, بهزاد and حسین خانی, علی and اصلانیان, رقیه and امانی, فیروز and ذاکری, آناهیتا (1396) تاثیر فلوکستین بر کیفیت زندگی بیماران سرطانی. Iranian Journal of Pharmacology and Therapeutics ــ 15 (1). pp. 1-5. شاپا 1735-2657

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Official URL: http://ijpt.iums.ac.ir/article-1-321-en.html


Effect of fluoxetine on quality of life in patients with solid cancers: a double-blind study

English Abstract

More studies showed that diagnosis of cancer lead to occurrence of emotional problems in patient and his family. Fluoxetine is an anti-depression drug that used for treatment of Depression, Obsessive compulsive disorder, Panic disorder and nervous incontinence. The aim of this study was investigate the effect of fluoxetine on quality of life in patients with solid cancers. This is a randomized controlled clinical trial that has been done on two groups of patients each with 70 patients. One group received fluoxetine for 12 weeks and another group received placebo. In baseline and end of study, SF36 questionnaire were completed for all patients and results analyzed by statistical methods in SPSS.16. The most prevalent malignancy in case and control groups was gastric cancer with 40% and 42.9%, respectively. There wasn’t significant difference in QOL of patients in baseline between two groups but in the end of study, emotional-psychological health and vitality scores in case group was better than control group. In terms of physical symptoms and depression, the case group was better than control group. In start and end of study, in QOL score only difference was seen in physical activity which was better in case group than control group. Results showed that fluoxetine prescription in patients could recovery some dimensions of QOL and general health but not effect on some dimensions which probably related to short duration of fluoxetine prescription in patients.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :اصغر پیرزاده
نویسنده :بهزاد محمدی
نویسنده :علی حسین خانی
نویسنده :رقیه اصلانیان
نویسنده :فیروز امانی
نویسنده مسئول :آناهیتا ذاکری
Additional Information:Indexed in: Google Scholar, SID, Magiran
کلیدواژه ها (انگلیسی):Solid cancer, Fluoxetine, QOL, General health
Subjects:QY Clinical Pathology
WT Geriatrics . Chronic Diseases
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
Faculty of Medicine > Department of Surgery
Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:11068
Deposited By: دکتر آناهیتا ذاکری
Deposited On:27 Sep 1397 17:16
Last Modified:21 Feb 1399 15:40

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