عصاره آقطی پاسخ های سلولی را در لیشمانیوز جلدی تحریک می کند

حیدری کرجی, مریم and فلاح عمرانی, وحید and بدیرزاده, علیرضا and محمدی قلعه بین, بهنام and نیلفروش زاده, محمد علی and ماسوری, لیلا and منتخب یگانه, حسین and زارع, مهراک (1397) عصاره آقطی پاسخ های سلولی را در لیشمانیوز جلدی تحریک می کند. Parasite Immunology ــ 41 (1). pp. 1-11. شاپا 0141-9838

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Official URL: https://onlinelibrary.wiley.com/doi/10.1111/pim.12...


Sambucus ebulus extract stimulates cellular responses in cutaneous leishmaniasis

English Abstract

This is the first study aiming to determine the therapeutic effects of the Sambucus ebulus aquatic extract as an antileishmanial herbal drug and evaluate the immune responses in Leishmania major major infected BALB/c mice. The antileishmanial activity of S ebulus aquatic extract was evaluated using MTT test as well as parasite rescue and transformation assay. Footpad swelling and parasite load of infected mice were measured by several techniques. The immune responses were evaluated by measuring the levels of IFN‐γ, IL‐4, nitric oxide and arginase. The results indicated that S. ebulus can significantly decrease L. major promastigotes and amastigotes viability, but it was not toxic to macrophages. The lesion size, parasite burden and the level of ARG decreased in the treated infected mice, while the IFN‐γ‐to‐IL‐4 ratio and the level of NO increased significantly. Altogether, the S. ebulus extract is an effective compound for killing Leishmania parasite without excessive toxicity to the host cells and can cure the CL by switching the host immune responses towards Th1 response. Thus, it may be a perfect therapeutic option for CL treatment.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :مریم حیدری کرجی
نویسنده مسئول :علیرضا بدیرزاده
نویسنده :بهنام محمدی قلعه بین
Additional Information:Impact Factor(2017) 2.836 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, Chemical Abstracts Service, Embase, Biological Abstracts, Current Contents: Life Sciences
کلیدواژه ها (انگلیسی):BALB/c, CC50, Cutaneous leishmaniasis, EC50, IC50, Leishmania major, Sambucus ebulus L
Subjects:QX Parasitology
QV pharmacology > QV 766 Plants, Medicinal
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Parasitology
ID Code:11105
Deposited By: Dr Behnam Mohammadi Ghalebin
Deposited On:02 Oct 1397 13:17
Last Modified:02 Oct 1397 13:17

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