title

بربرین اثر هیپوکسیک ایسکمیک را در مغز نوزاد موش کم میکند

Benaissa, F and محمودیان, مسعود and محسنی راد, حامد (1388) بربرین اثر هیپوکسیک ایسکمیک را در مغز نوزاد موش کم میکند. Acta Physiologica Hungarica ــ 96 (2). pp. 213-220. شاپا 0231-424X

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Official URL: https://akademiai.com/doi/abs/10.1556/APhysiol.96....


Title

Berberine reduces the hypoxic-ischemic insult in rat pup brain

English Abstract

Berberine, an isoquinoline alkaloid extracted from medicinal herbs, has been used as antipyretic, antidiarrheal, bactericide and anti-inflammatory agent. In this study, berberine effects on neuronal damage have been examined. The right carotid artery of seven-day-old rat pups was ligated (ischemic insult), then berberine solution (0.2, 0.5, 1 or 2 mg/kg) was injected intra-peritoneally, and 30 minutes later pups were passed through hypoxic condition with breathing in air containing 10% oxygen and 90% nitrogen(hypoxic insult). The day after that the brains of pups were enucleated for pathologic assessment. Pathologic review of the samples obtained from rats treated with different doses of berberine in comparison with samples from pups treated by normal saline showed that there was a significant reduction of brain injury and edema in the rats treated with berberine. Our study also demonstrates that berberine reduces brain ischemic-hypoxic injury dose-dependently. Therefore, beberine may be considered as useful anti-stroke agent.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :F Benaissa
نویسنده مسئول :مسعود محمودیان
نویسنده :حامد محسنی راد
Additional Information:IF(2009):0.750 Indexing in: ISI, Scopus,Pubmed/medline, Index copernicus, Google scholar
کلیدواژه ها (انگلیسی):berberine, hypoxic-ischemic insult, brain edema, rat pups, neuronal damage, brain injury, anti-stroke agent
Subjects:QV pharmacology > QV 754 Clinical Pharmacy
WL Nervous system
Divisions:Faculty of Medicine > Department of Surgery
ID Code:11147
Deposited By: دکتر حامد محسنی راد
Deposited On:01 Apr 1398 08:19
Last Modified:04 Apr 1398 10:23

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