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سطح سمینال IGF1 ممکن است که در پاتوفیزولوژی ناباروری در مردان مبتلا به واریکوسل موثر باشد.

نادری, غلامحسین ، محسنی راد, حامد ، تبسمی, فیروزه ، لطیف, امیرحسین (1394) سطح سمینال IGF1 ممکن است که در پاتوفیزولوژی ناباروری در مردان مبتلا به واریکوسل موثر باشد. Human Fertility ــ 18 (2). ص.ص.92-95. شاپا 1464-7273

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آدرس اینترنتی رسمی : https://www.tandfonline.com/doi/full/10.3109/14647...


عنوان انگليسی

Seminal insulin-like growth factor-I may be involved in the pathophysiology of infertility among patients with clinical varicocele

خلاصه انگلیسی

Varicocele, the most common cause of male infertility, is defined as abnormal dilation of the pampiniform plexus. Although different mechanisms have been proposed to explain the pathophysiology of infertility caused by varicocele, it is still open to debate. Previous studies have demonstrated the effect of insulin-like growth factor-I (IGF-I) on semen quality in animals and humans, but there are no studies on the probable role of seminal IGF-I in the pathophysiology of infertility among patients with clinical varicocele. We therefore aimed to examine the seminal IGF-I concentration in 49 patients with varicocele and primary infertility before and after varicocelectomy and compare the results with those of 50 healthy fertile men (in the control group). Mean seminal IGF-I level of patients before varicocelectomy (93.7 ± 67.2 ng/mL) was significantly different (P < 0.001) from that following varicocelectomy (58 ± 35.1 ng/mL) and from that of the controls (57.6 ± 22.1 ng/mL). However, mean seminal IGF-I levels of patients after varicocelectomy and the controls were not significantly different. Seminal IGF-I level was not correlated with grade and side of varicocele, and semen quality. We conclude that locally secreted IGF-I in the semen may be involved in the pathophysiology of infertility in patients with varicocele or semen.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :غلامحسین نادری
نویسنده :حامد محسنی راد
نویسنده :فیروزه تبسمی
نویسنده مسئول :امیرحسین لطیف
ضریب تاثیر و نمایه مجلات:IF(2015):0.988 Indexed in: ISI, PubMed/Medline, Scopus, Index medicus, Google scholar, Embase
کلیدواژه ها (انگلیسی):Insulin-like growth factor-I , varicocele , semen analysis , infertility , Iran
موضوعات :WJ سیستم ادراری
بخش های دانشگاهی :دانشكده پزشكي > گروه جراحی
کد شناسایی :11152
ارائه شده توسط : دکتر حامد محسنی راد
ارائه شده در تاریخ :04 تیر 1398 08:57
آخرین تغییر :06 تیر 1398 16:20

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