بررسی ماکروفاژهای همراه تومور در کارسینومای مجرایی مهاجم در سرطان پستان انسان با روش فلوسایتومتری

امانی, داور and حسن, زهیر محمد and روانگرد, فاطمه and فرازمند, سوسن and کریم زاده, مجتبی (1384) بررسی ماکروفاژهای همراه تومور در کارسینومای مجرایی مهاجم در سرطان پستان انسان با روش فلوسایتومتری. Iranian Journal of Immunology ــ 2 (2). pp. 117-122. شاپا 1735-1383

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Official URL: http://iji.sums.ac.ir/


Flowcytometric Analysis of Tumor Associated Macrophages in Invasive Ductal Carcinoma of Breast

English Abstract

Background: Invasive ductal carcinoma is the most common type of breast cancer in Iran. Impaired immune responses occur frequently in cancer patients, but the mechanisms of the induced immune defects remain poorly understood. It is believed that infiltrated immune cells, especially macrophages, may provide help for tumor cell growth and metastasis. Objective: To analyze the status of tumor associated macrophages (TAM) by immunophenotyping method. Methods: Twenty-three women suffering from breast cancer were examined; nineteen of them were confirmed histologically to have invasive ductal carcinoma. Tumor cell suspensions from biopsy specimens and peripheral blood mononuclear cells from patients and matched controls were processed for analysis by flow cytometry. Results: No significant changes in the percentages of intra-tumor leukocytes and macrophages in the different stages of tumor were observed. There were no significant differences in the percentages of leukocytes (CD45+), monocytes CD45+/CD14+) and activated monocytes (CD14+/HLA-DR+ and CD14+/CD16+) in the peripheral blood of patients and controls. Conclusion: The results of this study indicated that human breast cancer contain substantial, although variable numbers of macrophages, however, the activation status of these macrophages remain to be elucidated.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :داور امانی
کلیدواژه ها (انگلیسی):Breast Cancer, Tumor Associated Macrophages, Tumor Immunity
Subjects:WP Gynecology
QZ Pathology
QW Microbiology and Immunology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Immunology
ID Code:1130
Deposited By: Dr Davar Amani
Deposited On:20 Dec 1388 12:27
Last Modified:07 Jul 1393 05:05

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