تعامل MAML1 با EGR1 و نقش آن در نفروژنز و توسعه سرطان کلیوی

Hansson, Magnus L and Behmer, Stefanie and Ceder, Rebecca and محمدی, پرهام سعداله and Preta, Giulio and Grafstrom, Roland C and Fadeel, Bengt and Wallberg, Annika E (1391) تعامل MAML1 با EGR1 و نقش آن در نفروژنز و توسعه سرطان کلیوی. PloS ONE ــ 7 (9). pp. 1-9. شاپا 1932-6203

Text - Published Version

Official URL: https://journals.plos.org/plosone/article?id=10.13...


MAML1 acts cooperatively with EGR1 to activate EGR1-regulated promoters: implications for nephrogenesis and the development of renal cancer.

English Abstract

Mastermind-like 1 (MAML1) is a transcriptional coregulator of activators in various signaling pathways, such as Notch, p53, myocyte enhancer factor 2C (MEF2C) and beta-catenin. In earlier studies, we demonstrated that MAML1 enhanced p300 acetyltransferase activity, which increased the acetylation of Notch by p300. In this study, we show that MAML1 strongly induced acetylation of the transcription factor early growth response-1 (EGR1) by p300, and increased EGR1 protein expression in embryonic kidney cells. EGR1 mRNA transcripts were also upregulated in the presence of MAML1. We show that MAML1 physically interacted with, and acted cooperatively with EGR1 to increase transcriptional activity of the EGR1 and p300 promoters, which both contain EGR1 binding sites. Bioinformatics assessment revealed a correlation between p300, EGR1 and MAML1 copy number and mRNA alterations in renal clear cell carcinoma and p300, EGR1 and MAML1 gene alterations were associated with increased overall survival. Our findings suggest MAML1 may be a component of the transcriptional networks which regulate EGR1 target genes during nephrogenesis and could also have implications for the development of renal cell carcinoma.

Item Type:Article
زبان سند : انگلیسی
نویسنده :پرهام سعداله محمدی
Additional Information:IF: 3.730 Indexed In: ISI, Scopus, PubMed, Embase, DOAJ
کلیدواژه ها (انگلیسی):Kidney Neoplasms , EGR1 , cooperatively , renal cancer
Subjects:QV pharmacology
Divisions:School of Pharmacy > Department of Pharmacology
ID Code:11465
Deposited By: MS Soghra Golmaghani
Deposited On:10 Nov 1397 09:13
Last Modified:12 Dec 1397 13:15

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