title

مکمل روی باعث کاهش شاخص های دیابتی در بیماران مبتلا به رتینوپاتی دیابتی می شود

نقی زاده, سیامک and خیروری, ثریا and اوجاقی, حبیب and جعفری کفاش, احد (1397) مکمل روی باعث کاهش شاخص های دیابتی در بیماران مبتلا به رتینوپاتی دیابتی می شود. Progress in Nutrition ــ 20 (S2). pp. 263-269. شاپا 1129-8723

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Title

Zinc supplementation attenuate diabetic indices in patients with diabetic retinopathy

English Abstract

Aim: Zinc (Zn) deficiency has been shown to be associated with age-related eye diseases, such as diabetic retinopathy. Blood sugar and blood pressure are prognostic factors in diabetic retinopathy. The aim of this study was to evaluate the effects of zinc supplementation on diabetes indices and blood pressure in patients with non-proliferative diabetic retinopathy. Patients and Methods: 45 patients with non-proliferative diabetic retinopathy (20 males and 25 females) aged from 40 to 70 years were participated in current double-blind randomized placebo-controlled trial. The disease was diagnosed by an expert ophthalmologist according to early photocoagulation and diabetic retinopathy criteria. The patients were assigned to intervention (23 patients) and placebo (n = 22) groups. The groups received zinc (as zinc gluconate; 30 mg) and placebo (maltodextrin; 30 mg) for 3 months, respectively. Fasting insulin, fasting glucose, insulin resistance index (HOMA-IR), hemoglobin A1c (HbA1c), systolic blood pressure (SBP), diastolic blood pressure (DBP) and serum zinc levels were measured before and after the intervention in the both groups. Results: Zinc supplementation significantly increased serum zinc (P= 0.004) and decreased serum insulin levels (P= 0.008), fasting blood sugar (FBS) (P= 0.011), HOMA-IR (P= 0.002) and SBP (P= 0.017) in the intervention group compared with placebo group. The intervention had no significant effects on DBP, HbA1c. Conclusion: Due to the positive effects of zinc supplementation on prognostic factors of diabetic retinopathy, it seems complementary therapy with zinc is needed in these patients.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :سیامک نقی زاده
نویسنده مسئول :ثریا خیروری
نویسنده :حبیب اوجاقی
Additional Information:Impact Factor (2017) 0.323 Indexed in: ISI, Scopus, Embase
کلیدواژه ها (انگلیسی):diabetic retinopathy, zinc supplementation, FBS, Insulin, HbA1c, Blood pressure
Subjects:WW Ophthalmology
Divisions:Faculty of Medicine > Department of Surgery
ID Code:11569
Deposited By: Ms Zeynab Imani
Deposited On:11 Dec 1397 14:29
Last Modified:13 Dec 1397 09:50

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