title

مطالعه اثرات ال کارنیتین بر روی عملکرد همودینامیک میوکارد

نجفی, مسلم and جاویدنیا, علی and قربانی حق جو, امیر and محمدی, پرهام سعداله and گرجانی, علیرضا (1389) مطالعه اثرات ال کارنیتین بر روی عملکرد همودینامیک میوکارد. Pakistan Journal of Pharmaceutical Sciences ــ 23 (3). pp. 250-255. شاپا 1011-601X

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Title

Pharmacological preconditioning with L-carnitine: relevance to myocardial hemodynamic function and glycogen and lactate content

English Abstract

Carnitine is a vital biologic substance facilitating fatty acids transport into mitochondria for ATP production. This study was to investigate the effects of pre-ischemic pharmacological preconditioning (PC) with L-carnitine (L-Car) on myocardial infarct size and cardiac functions in ischemic and reperfused isolated rat heart and meanwhile on left ventricular glycogen and lactate content. Isolated rat hearts were subjected to 30 min coronary artery occlusion followed by 120 min reperfusion. The hearts (n= 8-12) were perfused with L-Car (0.5-5 mM) only for 15 min before to 10 min after induction of ischemia. Preconditioning of the hearts with L-Car provided concentration-dependent cardioprotection as evidenced by improved postischemic ventricular functional recovery (developed pressure, left ventricular end diastolic pressure and coronary flow rate) and reduced myocardial infarct size (p<0.001). L-Car (2.5 mM) decreased both glycogen (p<0.001) and lactate (p>0.05) content in left ventricle during ischemia compared with the control. The results of this study demonstrate that L-Car pharmacologically precondition the hearts against ischemic and reperfusion injury in part by recovery of postischemic ventricular hemodynamic functions, depletion of glycogen and therefore reduction of lactate accumulation.

Item Type:Article
نویسنده اول :مسلم نجفی
نویسنده :علی جاویدنیا
نویسنده :امیر قربانی حق جو
نویسنده :پرهام سعداله محمدی
نویسنده مسئول :علیرضا گرجانی
Additional Information:IF: 0728 Indexed in: ISI , Scopus , MEDLINE/PubMed,
کلیدواژه ها (انگلیسی):L-carnitine, preconditioning, glycogen, lactate, isolated rat heart.
Subjects:QV pharmacology
Divisions:School of Pharmacy > Department of Pharmacology
ID Code:11600
Deposited By: MS Soghra Golmaghani
Deposited On:20 Dec 1397 12:14
Last Modified:20 Dec 1397 12:14

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