اسید اوکادائیک شکل پذیری سیناپسی کوتاه مدت و طولانی مدت نورونهای واقع در شکنج دندانه ای هیپوکامپ را کاهش میدهد

حمیدی, نسرین and نوزاد, عبدالله and شیخکانلوی میلان, حمید and امانی, محمد (1397) اسید اوکادائیک شکل پذیری سیناپسی کوتاه مدت و طولانی مدت نورونهای واقع در شکنج دندانه ای هیپوکامپ را کاهش میدهد. Neurobiology of Learning and Memory ــ 158 . pp. 24-31. شاپا 1074-7427

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Okadaic acid attenuates short-term and long-term synaptic plasticity of hippocampal dentate gyrus neurons in rats

English Abstract

Protein phosphorylation states have a pivotal role in regulation of synaptic plasticity and long-term modulation of synaptic transmission. Serine/threonine protein phosphatase 1 (PP1) and 2A (PP2A) have a critical effect on various regulatory mechanisms involved in synaptic plasticity, learning and memory. Okadaic acid (OKA), a potent inhibitor of PP1 and PP2A, reportedly leads to cognitive decline and Alzheimer’s disease (AD)-like pathology. The aim of this study was to examine the effect of OKA on electrophysiological characteristics of hippocampal dentate gyrus (DG) neurons in vivo. Male Wistar rats were divided into two control and OKA groups. OKA was injected intracerebroventricularly (i.c.v.) into lateral ventricles and after two weeks the long-term potentiation (LTP) and paired-pulse responses recorded from hippocampal perforant path-DG synapses in order to assess short-term and long-term synaptic plasticity. Results of this study revealed that OKA-induced inhibition of PP1 and PP2A activity drastically attenuates the field excitatory postsynaptic potential (fEPSP) slope and population spike (PS) amplitude following paired pulse and high frequency stimulation (HFS) of hippocampal DG neurons indicating pre- and post-synaptic involvement in electrical activity of these neurons. Administration of OKA impaired the short-term and long-term spatial memories conducted by Y-maze and passive avoidance tests, respectively. OKA-induced attenuation in electrophysiological activity and consequent memory deficits also provide a beneficial tool for studying neurodegenerative disorders such as AD.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :نسرین حمیدی
نویسنده :عبدالله نوزاد
نویسنده :حمید شیخکانلوی میلان
نویسنده مسئول :محمد امانی
Additional Information:Impact Factor (2017) 3.244 Indexed in: ISI, Pubmed/Medline/Index Medicus, Embase
کلیدواژه ها (انگلیسی):Okadaic acid,Protein phosphatase,Synaptic plasticity,Dentate gyrus
Subjects:QT physiology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:11633
Deposited By: Dr Hamid Sheikhkanloui Milan
Deposited On:07 Jan 1398 12:05
Last Modified:07 Jan 1398 12:05

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