نقش هورمونها در بیماری و آسیب ایسکمی-رپرفیوژن کلیه

بنایی, شکوفه and رضاقلی زاده, لطف اله (1398) نقش هورمونها در بیماری و آسیب ایسکمی-رپرفیوژن کلیه. Iranian Journal of Basic Medical Sciences ــ 22 (5). pp. 469-476. شاپا 2008-3866

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The role of hormones in renal disease and ischemia reperfusion injury

English Abstract

The patients with renal diseases, especially end-stage renal disease (ESRD), are at high risk of developing cardiovascular disturbances. Some hormones such as brain natriuretic peptide appear to be important serum biomarkers in predicting cardiac death in ESRD patients. Renal diseases cause inflammation, anemia, uremic toxins, fluid overload, and electrolyte disturbance. Kidney transplantation is considered the choice treatment for patients with ESRD. Ischemia-reperfusion (IR), which occurs during renal transplantation is one of the factors that affect the outcome of renal transplantation. Renal graft rejection is the result of IR injury and there is no effective treatment to prevent IR injury. Reperfusion after ischemia may cause injury through generation of reactive oxygen and nitrogen species, inflammatory responses by increased levels of tumor necrosis factor-α (TNF-α) and interleukins (IL), and apoptotic processes, and leads to acute kidney injury (AKI). Thus, antioxidant, anti-apoptotic and anti-inflammatory hormones, which inhibit these pathways, can protect against IR injury and improve transplanted renal function in patients with ESRD.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :شکوفه بنایی
نویسنده :لطف اله رضاقلی زاده
Additional Information:IF(2018): 1.854 Indexed in: ISI, Pubmed/PMC, Scopus, EMBASE, Chemical Abstracts , Google Scholar, DOAJ, ISC, Magiran
کلیدواژه ها (انگلیسی):Acute kidney injury Antioxidant; Hormones; Ischemia-reperfusion injury; Renal disease
Subjects:QT physiology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Biochemistry
Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:11676
Deposited By: ms shokofeh banaei kivi
Deposited On:28 Jan 1398 15:51
Last Modified:23 Jun 1398 13:47

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