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مقاله مروری: تاثیر ملاتونین در شیمی درمانی سرطان های انسانی

نجفی, مسعود ، صالحی, انسیه ، فرهود, باقر ، شعبانی, مریم ، هاشمی, ناصر ، خانلرخانی, ندا ، نامجو, زینب ، مرتضایی, کیوان (1398) مقاله مروری: تاثیر ملاتونین در شیمی درمانی سرطان های انسانی. Journal of Cellular Physiology ــ 234 (3). ص.ص.2356-2372. شاپا 0021-9541

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آدرس اینترنتی رسمی : https://onlinelibrary.wiley.com/doi/10.1002/jcp.27...


عنوان انگليسی

Adjuvant chemotherapy withmelatoninfortargeting human cancers:Areview

خلاصه انگلیسی

differentially influence tumors from normal cells. In this review, the roles of melatonin adjuvant therapy in human cancer are discussed. Combination of melatonin with chemotherapy could provide synergistic antitumoral outcomes and resolve drug resistance in affected patients. This combination reduces the dosage for chemotherapeutic agents with the subsequent attenuation of side effects related to these drugs on normal cells around tumor and on healthy organs. The combination therapy increases the rate of survival and improves the quality of life in affected patients. Cancer cell viability is reduced after application of the combinational melatonin therapy. Melatonin does all these functions by adjusting the signals involved in cancer progression, re‐establishing the dark/light circadian rhythm, and disrupting the redox system for cancer cells. To achieve effective therapeutic outcomes, melatonin concentration along with the time of incubation for this indoleamine needs to be adjusted. Importantly, a special focus is required to be made on choosing an appropriate chemotherapy agent for using in combination with melatonin. Because of different sensitivities of cancer cells for melatonin combination therapy, cancer‐specific targeted therapy is also needed to be considered. For this review, the PubMed database was searched for relevant articles based on the quality of journals, the novelty of articles published by the journals, and the number of citations per year focusing only on human cancers.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :مسعود نجفی
نویسنده :انسیه صالحی
نویسنده :باقر فرهود
نویسنده :زینب نامجو
نویسنده مسئول :کیوان مرتضایی
ضریب تاثیر و نمایه مجلات:Impact Factor (2018):4.522 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, Embase, Chemical Abstracts Service
کلیدواژه ها (انگلیسی):apoptosis, cancer, chemotherapy, melatonin, viability
موضوعات :QU بیوشیمی
بخش های دانشگاهی :دانشكده پزشكي > گروه علوم پایه > بخش علوم تشريح
کد شناسایی :11722
ارائه شده توسط : دکتر زینب نامجو
ارائه شده در تاریخ :15 اردبهشت 1398 13:15
آخرین تغییر :31 تیر 1398 11:00

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