نقش متناقض سلول های Th17 در پاسخ ایمنی ضد توموری

اسدزاده, زهرا and محمدی, حامد and صفرزاده, الهام and همت زاده, مریم and مهدیان شکیب, احمد and جدیدی, فرهاد and عزیزی, غلامرضا and برادران, بهزاد (1396) نقش متناقض سلول های Th17 در پاسخ ایمنی ضد توموری. Cellular Immunology ــ 322 . pp. 15-25. شاپا 0008-8749

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The paradox of Th17 cell functions in tumor immunity

English Abstract

Immune system acts as a host defensive mechanism protecting against attacking pathogens and transformed cells, including cancer cells. Th17 cells are a specific subset of T helper lymphocytes determined by high secretion of IL-17 and other inflammatory cytokines. Th17 cells increase tumor progression by activating angiogenesis and immunosuppressive activities. They can also mediate antitumor immune responses through recruiting immune cells into tumors, stimulating effector CD8+ T cells, or surprisingly by altering toward Th1 phenotype and producing IFN-γ, so Th17 cells are supposed as a double-edged sword in cancer. A comprehensive approach to indicating the activity of Th17 cells in tumor progression could help in the planning of new therapeutic approaches specially targeting Th17 cells in cancer.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :زهرا اسدزاده
نویسنده :الهام صفرزاده
Additional Information:IF: 2.995 Indexed in: ISI, Scopus, PubMed/Medline, Embase
کلیدواژه ها (انگلیسی):Th17 cells , IL-17 cytokine , Pro-tumor , Anti-tumor , Angiogenesis
Subjects:QW Microbiology and Immunology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Immunology
ID Code:11734
Deposited By: Dr elham safarzadeh
Deposited On:19 Mar 1398 14:42
Last Modified:19 Mar 1398 14:42

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