title

سلول سرکوب گر از رده مایلوییدی: سلول های مهم در پیشرفت و متاستاز تومور

صفرزاده, الهام and اورنگی, مونا and محمدی, حامد and بابایی, فرهاد and برادران, بهزاد (1397) سلول سرکوب گر از رده مایلوییدی: سلول های مهم در پیشرفت و متاستاز تومور. Journal of Cellular Physiology ــ 233 (4). pp. 3024-3036. شاپا 0021-9541

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Official URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/jc...


Title

Myeloid-derived Suppressor Cells: important contributors to tumor progression and metastasis

English Abstract

Myeloid-derived suppressor cells (MDSCs) are traditionally considered among the major components of the immunosuppressive tumor microenvironment. However, there is currently increasing evidence indicating that MDSCs in addition to suppression of immune surveillance is also involved in an array of non-immunological functions like augmenting metastatic potential of tumor cells. Indeed, MDSCs can promote metastasis in animal models and cancer patients through promoting premetastatic niche formation, tumor angiogenesis and invasion. Moreover, MDSC frequency and function have been associated with progressive disease and correlated with clinical outcome. This review will summarize and discusses the data demonstrating the role for MDSCs in tumor metastasis. This article is protected by copyright.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :الهام صفرزاده
نویسنده :مونا اورنگی
نویسنده :حامد محمدی
نویسنده :فرهاد بابایی
نویسنده مسئول :بهزاد برادران
Additional Information:IF(2017): 3.923 Index in: ISI, Pubmed/Medline, Index medicus, Google scholar
کلیدواژه ها (انگلیسی):angiogenesis, cancer, metastasis, myeloid-derived suppressor cells (MDSCs), tumor microenvironment
Subjects:QW Microbiology and Immunology
QZ Pathology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Immunology
Faculty of Medicine > Department of Basic Sciences > Department of Microbiology
ID Code:11748
Deposited By: Dr elham safarzadeh
Deposited On:19 Mar 1398 12:29
Last Modified:19 Mar 1398 12:30

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