نقش آدنوزین و آدنوزین رسپتورها در بیماری مالتیپیل اسکلروزیز

صفرزاده, الهام and جدیدی, فرهاد and مطلب نژاد, مرتضی and یوسفی, مهدی (1395) نقش آدنوزین و آدنوزین رسپتورها در بیماری مالتیپیل اسکلروزیز. Inflammation Research ــ 65 (7). pp. 511-520. شاپا 1023-3830

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Official URL: https://link.springer.com/article/10.1007/s00011-0...


The role of adenosine and adenosine receptors in the immunopathogenesis of multiple sclerosis

English Abstract

Introduction Multiple sclerosis (MS) is a heterogeneous neurological disorder with multifactorial etiologies characterized by demyelination, axonal degeneration, and oligodendroglial death. It is believed that both genetics and environmental risk factors such as infection are involved in disease etiology. Accumulating evidence indicates that alteration in purinergic system signaling is involved in immunity and inflammation. Adenosine, a key purine nucleoside, has been shown to be produced during metabolic stress, including ischemia, inflammatory condition, and tissue injury. Methods Extracellular adenosine directly affects various physiological and pathological processes of MS by stimulating G protein-coupled adenosine receptors A1, A2A, A2B, and A3 on the surface of immune cells. It has been suggested that promotion of adenosinergic system may be an important factor in MS pathophysiology and considered as promising therapeutic target for this disease. Conclusion In this review, we will discuss about the immunopathologic effects of adenosine on MS and its animal model, experimental autoimmune encephalomyelitis

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :الهام صفرزاده
نویسنده :فرهاد جدیدی
نویسنده :مرتضی مطلب نژاد
نویسنده مسئول :مهدی یوسفی
Additional Information:IF(2017):2.99 Indexed in: ISI, Pubmed/Medline, Scopus
کلیدواژه ها (انگلیسی):Adenosine, Adenosine receptor, Multiple sclerosis, Experimental autoimmune encephalomyelitis
Subjects:QW Microbiology and Immunology
WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Immunology
Faculty of Medicine > Department of Basic Sciences > Department of Microbiology
ID Code:11749
Deposited By: Dr elham safarzadeh
Deposited On:19 Mar 1398 10:44
Last Modified:20 Jun 1400 12:32

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