نقش میکروبیوتای دستگاه گوارش و مسیر اینترلوکین 23 و 17 در ایمونوپاتوژنز بیماری اسپوندیلیت انکیلوزان

بابایی, فرهاد and حسن خانی, میلاد and محمدی, حامد and صفرزاده, الهام and رضائی منش, علیرضا and سلیمی, رضا and برادران, بهزاد and بابالو, زهره (1397) نقش میکروبیوتای دستگاه گوارش و مسیر اینترلوکین 23 و 17 در ایمونوپاتوژنز بیماری اسپوندیلیت انکیلوزان. Immunology Letters ــ 196 . pp. 52-62. شاپا 0165-2478

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The role of gut microbiota and IL-23/IL-17 pathway in ankylosing spondylitis immunopathogenesis: New insights and updates

English Abstract

Ankylosing spondylitis (AS) is a type of arthritis that is referred to a group of chronic immune-mediated inflammatory diseases termed as seronegative spondyloarthropathies or spondyloarthritides. It typically affects the joints of the spinal and axial skeleton and exhibits common clinical features and genetic factors such as human leukocyte antigen class I allele HLA-B27, the Endoplasmic Reticulum Aminopeptidase 1 (ERAP1), and environmental factors such as microbial triggers. Although the precise etiopathogenic mechanisms that implicate the pathogenesis of AS have still remained to be clarified, the IL-23/IL-17 immune axis has been detected as an important factor in the immunopathogenesis of AS. Moreover, therapeutic options targeting this signaling pathway have been demonstrated to be effective in various other inflammatory diseases that share similar genetic etiology and pathogenetic pathways. In mammalian intestinal, there are trillions of commensal microbes that create the intricate symbiotic relationship with host well-known as the microbiota and play the major role in human health and disease. Several publications have appeared in recent years documenting the pivotal role of the gut microbiota and the IL-23/IL-17 pathway in the pathogenesis of spondyloarthritides. In this review, several points are discussed and summarized including recent advances on the role of the IL-17/IL-23 immune pathway in the pathogenesis of AS, HLA-B27, and ERAP 1 and 2 mediated pathogenesis, AS-related microbiota compositions, and new potential therapies for AS.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :فرهاد بابایی
نویسنده :میلاد حسن خانی
نویسنده :حامد محمدی
نویسنده :الهام صفرزاده
نویسنده :علیرضا رضائی منش
نویسنده :رضا سلیمی
نویسنده مسئول :بهزاد برادران
نویسنده مسئول :زهره بابالو
Additional Information:IF(2017): 2.436 Indexing in: ISI, Pubmed/Medline, Scopus
کلیدواژه ها (انگلیسی):Ankylosing spondylitis, Dysbiosis, ERAP1, IL-17, IL-23, Microbiome, Therapy
Subjects:QW Microbiology and Immunology
WI Digestive System
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Immunology
ID Code:11750
Deposited By: Dr elham safarzadeh
Deposited On:19 Mar 1398 09:24
Last Modified:19 Mar 1398 10:03

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