اینترکشن سلول های بنیادی سرطانی، سلول های ایمنی و ریزمحیط تومور

عنوان انگليسی

Interactions between cancer stem cells, immune system and some environmental components: Friends or foes

خلاصه انگلیسی

Cancer stem cells (CSCs) are a subgroup of tumor cells that are characterized by their tumor initiating capacity,low proliferation rate, self-renewal capacity, pluripotency and chemoresistance. The immune system, includinginnate and adaptive immune cells, plays pro-tumorigenic and anti-tumorigenic roles in cancer biology.Immunosurveillance often initially successfully eradicates tumor cells. However, following a phenomenon re-ferred to as immunoediting, cancer cells may ultimately evade immune destruction, thus enabling tumor pro-gression. Here, we review how CSCs both escape immune destruction and foster establishment of an im-munosuppressive tumor microenvironment through intricate interactions with and recruitment of a broad rangeof immune cells, including natural killer (NK) cells, myeloid-derived suppressor cells (MDSCs), regulatory T cells(Tregs), tumor-associated macrophages (TAMs), cytotoxic T-lymphocytes (CTLs) and T helper (Th) cells. Furtherelucidation of CSC-immune cell interactions and the underlying signaling mechanisms will open up novel op-portunities to improve cancer immunotherapy

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