title

کارایی مقایسه اثر لیدوکایین با پاراستامول وریدی در کاهش درد ناشی از تزریق پروپوفول حین اینداکشن بیهوشی

محمدیان اردی, علی and یوسفیان, مهزاد and جلدیانی, سارا (1398) کارایی مقایسه اثر لیدوکایین با پاراستامول وریدی در کاهش درد ناشی از تزریق پروپوفول حین اینداکشن بیهوشی. International Journal of Pharmaceutical Research ــ 11 (1). pp. 1084-1088. شاپا 1674-0440

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Title

Efficacy of intravenous paracetamol dilutions compared with lidocaine for prevention of propofol-induced pain during induction of anesthesia

English Abstract

Background: Propofol is an intravenous anesthetic drug that is commonly used for induction of anesthesia; pain during induction of anesthesia with propofol is a common problem (with a prevalence of 28-90%) that can be distressful for patients. We aimed to compare the efficiency of intravenous paracetamol in different dilutions and lidocaine in prevention of propofol-induced pain. Methods: In this randomized, double-blind clinical trial, 200 patients scheduled for elective surgery under general anesthesia with propofol was randomly assigned to 4 groups of 50 persons. In Group 1, 40 mg lidocaine in 5 ml normal saline; in group 2, 2 mg/kg Paracetamol in 5 ml normal saline; in group 3, 2 mg/kg Paracetamol in 20 ml normal saline, and in group 4, 5 ml normal saline were injected as control. Then, 25% of the calculated dose of Propofol (2.5 mg/kg) was injected at a speed of 0.5 ml/sec and the patient’s pain was determined based on VRS score from 0-3. Then, general anesthesia was induced. Results: In the four groups, there were no statistically significant differences in terms of age and sex. The amount of pain in Lidocaine group was significantly lower, compared to the control group (P=0.001), in the paracetamol group (P=0.03), in the diluted paracetamol group (P=0.009), but there was no significant difference among the three groups in terms of pain reduction. Discussion: Both 2 mg/kg paracetamol in 5 ml normal saline and in 20 ml normal saline are as effective as 40 mg lidocaine in 5 ml normal saline.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :علی محمدیان اردی
نویسنده مسئول :مهزاد یوسفیان
Additional Information:Indexed In: Scopus
کلیدواژه ها (انگلیسی):Paracetamol ; Lidocaine ; Propofol-induced pain
Subjects:WO Surgery
Divisions:Faculty of Medicine > Department of Anesthesiology , Obstetrics & Gynecology
ID Code:11784
Deposited By: دکتر مهزاد یوسفیان
Deposited On:10 Apr 1398 09:45
Last Modified:31 Apr 1398 11:23

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