نانوذرات فولیک اسید کاربردی به عنوان حاملهای دارویی در سیستم های تحویل دارو

نرمانی, اصغر and رضوانی, ملینا and فرهود, باقر and درخور, پروانه and محمدنژاد, جواد and امینی, بهرام and رفاهی, سهیلا and عبدی قوشبلاغ, نورالدین (1398) نانوذرات فولیک اسید کاربردی به عنوان حاملهای دارویی در سیستم های تحویل دارو. Drug Development Research ــ 80 (4). pp. 404-424. شاپا 1098-2299

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Official URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/dd...


Folic Acid Functionalized Nanoparticles as Pharmaceutical Carriers in Drug Delivery Systems

English Abstract

Conventional chemotherapeutic approaches in cancer therapy such as surgery, che-motherapy, and radiotherapy have several disadvantages due to their nontargeteddistributions in the whole body. On the other hand, nanoparticles (NPs) based thera-pies are remarkably progressing to solve several limitations of conventional drugdelivery systems (DDSs) including nonspecific biodistribution and targeting, poorwater solubility, weak bioavailability and biodegradability, low pharmacokinetic prop-erties, and so forth. The enhanced permeability and retention effect escape from P-glycoprotein trap in cancer cells as a passive targeting mechanism, and activetargeting strategies are also other most important advantages of NPs in cancer diag-nosis and therapy. Folic acid (FA) is one of the biologic molecules which has beentargeted overexpressed-folic acid receptor (FR) on the surface of cancer cells. There-fore, conjugation of FA to NPs most easily enhances the FR-mediated targeting deliv-ery of therapeutic agents. Here, the recent works in FA which have been decoratedNPs-based DDSs are discussed and cancer therapy potency of these NPs in clinicaltrials are presented

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :اصغر نرمانی
نویسنده :ملینا رضوانی
نویسنده :باقر فرهود
نویسنده :پروانه درخور
نویسنده مسئول :جواد محمدنژاد
نویسنده :بهرام امینی
نویسنده :سهیلا رفاهی
نویسنده مسئول :نورالدین عبدی قوشبلاغ
Additional Information:IF(2018):1.742 Indexing in: ISI, Pubmed/medline, Scopus, Index medicus, Google scholar
Uncontrolled Keywords:درمان و تشخیص سرطان، اسید فولیک، نانوذرات، نانوتکنولوژی، دارورسانی هدفمند
کلیدواژه ها (انگلیسی):cancer diagnosis and therapy, folic acid, nanoparticles, nanotechnology, targeted drug delivery
Subjects:QV pharmacology > QV 778 Pharmaceutical Nanotechnology
QV pharmacology
WN Radiology . Diagnostic Imaging
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Medical Physics
Faculty of Medicine > Department of Basic Sciences > Department of Pharmacology
Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:11808
Deposited By: Dr Soheila Refahi
Deposited On:28 Mar 1398 10:33
Last Modified:31 Apr 1398 10:33

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