بررسی دولکستین و گاباپنتین در کاهش درد بیماران با استئوآرتریت زانو

انتشاری مقدم, افسانه and اعظمی, احد and عیسی زاده فر, خاطره and محبی, حامد and حبیب زاده, افشین and جهان پناه, پریناز (1398) بررسی دولکستین و گاباپنتین در کاهش درد بیماران با استئوآرتریت زانو. Clinical Rheumatology ــ online . pp. 1-8. شاپا 0770-3198

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Official URL: https://link.springer.com/article/10.1007/s10067-0...


Efficacy of duloxetine and gabapentin in pain reduction in patients with knee osteoarthritis

English Abstract

Introduction Knee osteoarthritis (OA) is a common form of arthritis in elders which can lead to reduced daily activity and quality of life. It is important to administer a proper treatment with high efficacy and low side effects. In this study, we evaluated the efficacy of duloxetine and gabapentin in patients with moderate to severe knee OA. Method In this randomized clinical trial, 150 patients with moderate to severe knee OA were randomly allocated to receive duloxetine 30 mg (n = 50), gabapentin 300 mg (n = 50), or acetaminophen 1000 mg (n = 50) all twice a day for 12 weeks. Pain severity using visual analogue scale (VAS) and functional status using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) were measured before, 2 weeks, 1 month, and 3 months after intervention. Results WOMAC total and its subscale score were significantly lower in duloxetine compared to gabapentin in 2 weeks and 1 months after intervention, with no significant difference at the end of the third month. Both gabapentin and duloxetine groups had significantly more reduction in pain VAS and WOMAC and its subscales compared to acetaminophen group, with no significant difference between groups. Conclusions Both gabapentin and duloxetine have similar and acceptable effects in pain reduction and improvement of functional status in patients with knee OA at the end of the third month’s treatment. Duloxetine effects begin from the first weeks, while gabapentin effects begin gradually with the best at the end of the third month.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :افسانه انتشاری مقدم
نویسنده :احد اعظمی
نویسنده :خاطره عیسی زاده فر
نویسنده مسئول :حامد محبی
نویسنده :افشین حبیب زاده
نویسنده :پریناز جهان پناه
Additional Information:Impact Factor(2017) 2.141 Indexed in: ISI, Pubmed/Medline/Indexe Medicus, Scopus, Embase, Google Scholar, Current Contents/Clinical Medicine,
کلیدواژه ها (انگلیسی):Duloxetine . Gabapentin . Knee osteoarthritis . Pain
Subjects:WE Musculoskeletal system
Divisions:Faculty of Medicine > Educational Development Office
Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:11814
Deposited By: Dr Khatereh Isazadehfar
Deposited On:28 Feb 1398 12:22
Last Modified:28 Feb 1398 12:22

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