title

مروری بر ساختارهای هتروسیکل نیتروژن دار مهم به عنوان عوامل ضد لیشمانیوز

رزاقی اصل, نیما and سپهری, ساقی and عبادی, احمد and کرمی, پری and نجات خواه, نگین (1398) مروری بر ساختارهای هتروسیکل نیتروژن دار مهم به عنوان عوامل ضد لیشمانیوز. Molecular Diversity ــ . pp. 1-45. شاپا 1381-1991 (In Press)

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Official URL: https://link.springer.com/article/10.1007%2Fs11030...


Title

Insights into the current status of privileged N-heterocycles as antileishmanial agents

English Abstract

Leishmania, one of the most important neglected tropical diseases, is endemic in several regions of the world and hence regarded as a serious threat to public health. Major difficulties with current chemotherapeutic agents raise issues such as toxicity, resistance, cost and other side effects. These issues necessitate development of potentially new chemical entities against diverse leishmanial species. Numerous natural and synthetic new antileishmanial molecules have been described for disease management. Careful inspection of scientific reports revealed that considerable amount of promising antileishmanial agents belonged to the nitrogen-containing heterocycles such as quinoline, triazole, pyrazole, imidazole, indole, pyrimidine, β-carboline, quinoxaline, quinazoline and benzimidazole. In this regard, enormous chemical data provide the opportunity for systematic elucidation of structural requirements against different leishmanial species. Within this representation, insights into the current status of privileged N-heterocycles as antileishmanial agents with particular emphasis on structure activity relationships are reviewed.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :نیما رزاقی اصل
نویسنده :ساقی سپهری
نویسنده :احمد عبادی
نویسنده :پری کرمی
نویسنده :نگین نجات خواه
Additional Information:IF(2018): 2.032 Indexing in: ISI, Pubmed/Medline, Index medicus, Scopus, Google scholar
کلیدواژه ها (انگلیسی):Leishmania, N-heterocycle, Chemotherapy, SAR
Subjects:QV pharmacology > QV 744 Medicinal Chemistry
QV pharmacology
Divisions:School of Pharmacy > Department of Medicinal Chemistry
ID Code:11848
Deposited By: Dr Nima Razzaghi-Asl
Deposited On:20 Mar 1398 15:07
Last Modified:31 Apr 1398 11:48

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