تشخیص پره ناتال پره اکلامپسی از طریق مولکولهای هورمون اژاد کننده کورتیکو تروفین و ep mrna جفتی پلاسمای مادر

حمدی, کبری and مبارکی, نوشین and صادقی, فرزانه and حکیمی, پروین and جلیل وند, فرانک (1397) تشخیص پره ناتال پره اکلامپسی از طریق مولکولهای هورمون اژاد کننده کورتیکو تروفین و ep mrna جفتی پلاسمای مادر. Journal of Biochemical Technology ــ . pp. 178-184. شاپا 0974-2328

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Official URL: https://jbiochemtech.com/en/article/prenatal-diagn...


Prenatal Diagnosis of Preeclampsia by Molecular of Circulating Corticotrophin-Releasing Hormone and Ep mRNA of Placental in Maternal Plasma

English Abstract

Objective: Preeclampsia (PE) is a common disorder in pregnancy. Corticotrophin-releasing hormone (CRH)ats through vasodilatory effects. The aim of this study is diagnosis of PE by molecular of circulating CRH and Ep mRNA of placental in maternal plasma. Material and methods: The study was performed in early pregnant women with PE (n= 28) and normal pregnant women (n=30) as control group, blood samples was taken from each mother. Total RNA was isolated from harvested plasma synthesized from RNA samples using reverse transcription kit (Gen net bio) by the instructions of the manufacturer. Results: The Results indicated that expression of CRH was significantly different amongwomen suffered from preeclamptic compare of healthy pregnant women. Conclusion: This study demonstrated that thosemRNA concentrations were increased in the plasma of PE patients compared with those of normalsubjects and suggest the opportunity to gain furtherinsight into pathological pregnancy through mRNA measurementsin maternal plasma.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :کبری حمدی
نویسنده مسئول :نوشین مبارکی
نویسنده :فرزانه صادقی
نویسنده :پروین حکیمی
نویسنده :فرانک جلیل وند
کلیدواژه ها (انگلیسی):Preechlampsia, Circulating Corticotrophin-Releasing Hormone, Diagnosis, mRNA
Subjects:WQ Obstetrics
Divisions:Faculty of Medicine > Department of Anesthesiology , Obstetrics & Gynecology
ID Code:11866
Deposited By: دکتر فرانک جلیل وند
Deposited On:23 Mar 1398 17:44
Last Modified:04 Sep 1398 14:59

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