title

مواجهه مادر باعث اختلال در عملکرد میتوکندری های مغز، کبد و قلب جنین موش می شود: توضیح سقط جنین وسمیت تولید مثل ناشی از پرفلورواکتانوئیک اسید

سلیمی, احمد and نیکوسیر جهرمی, مهنیا and پوراحمد, جلال (1398) مواجهه مادر باعث اختلال در عملکرد میتوکندری های مغز، کبد و قلب جنین موش می شود: توضیح سقط جنین وسمیت تولید مثل ناشی از پرفلورواکتانوئیک اسید. Environmental Toxicology ــ 34 (7). pp. 878-885. شاپا 1520-4081 (In Press)

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Official URL: https://onlinelibrary.wiley.com/doi/10.1002/tox.22...


Title

Maternal exposure causes mitochondrial dysfunction in brain, liver, and heart of mouse fetus: An explanation for perfluorooctanoic acid induced abortion and developmental toxicity

English Abstract

Perfluorooctanoic acid (PFOA) is an octanoic acid and is found in wildlife and humans. We have investigated mitochondrial toxicity in isolated mitochondria from, placenta, brain, liver, and heart after oral exposure with PFOA in mice during gestational days (7‐15). Histopathological examination and mitochondrial toxicity parameters were assayed. Results indicated that PFOA decreased the weight of the fetus and placenta, the length of the fetus and the diameter of the placenta, dead fetuses and dead macerated fetuses in treated mice with 25 mg/kg. Histopathological examination showed that PFOA induced pathological abnormalities in liver, brain, heart, and placenta. Also, PFOA induced mitochondria toxicity in brain, liver, heart of mouse fetus. Our results indicate that PFOA up to 20 mg/kg exposure adversely affect embryofetal/developmental because for mitochondria dysfunction. These results suggested that mitochondrial dysfunction induced by PFOA in liver, heart, and brain lead to developmental toxicity and abnormality in tissues.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :احمد سلیمی
نویسنده :مهنیا نیکوسیر جهرمی
نویسنده مسئول :جلال پوراحمد
Additional Information:IF(2018): 2.649 Indexing in: ISI, Pubmed/Medline, Scopus, Index medicus, Google scholar
کلیدواژه ها (انگلیسی):developmental toxicity, embryo-fetal toxicity, mitochondria, perfluorooctanoic acid (PFOA
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:11895
Deposited By: دکتر احمد سلیمی
Deposited On:20 Mar 1398 11:29
Last Modified:27 Apr 1398 12:22

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