title

بینشهایی در وضعیت اخیر N-هتروسیکل های خاص به عنوان عوامل ضد لیشمانیا

رزاقی اصل, نیما and سپهری, ساقی and عبادی, احمد and کرمی, پری and نجات خواه, نگین and جوهری اهر, محمد (1398) بینشهایی در وضعیت اخیر N-هتروسیکل های خاص به عنوان عوامل ضد لیشمانیا. Molecular Diversity ــ . pp. 1-45. شاپا 1381-1991 (In Press)

[img] Text - Published Version
محدود به Repository staff only

6MB

Official URL: https://link.springer.com/article/10.1007/s11030-0...


Title

Insights into the current status of privileged N‑heterocycles as antileishmanial agents

English Abstract

Abstract: Leishmania, one of the most important neglected tropical diseases, is endemic in several regions of the world and hence regarded as a serious threat to public health. Major difficulties with current chemotherapeutic agents raise issues such as toxicity, resistance, cost and other side effects. These issues necessitate development of potentially new chemical entities against diverse leishmanial species. Numerous natural and synthetic new antileishmanial molecules have been described for disease management. Careful inspection of scientific reports revealed that considerable amount of promising antileishmanial agents belonged to the nitrogen-containing heterocycles such as quinoline, triazole, pyrazole, imidazole, indole, pyrimidine, β-carboline, quinoxaline, quinazoline and benzimidazole. In this regard, enormous chemical data provide the opportunity for systematic elucidation of structural requirements against different leishmanial species. Within this representation, insights into the current status of privileged N-heterocycles as antileishmanial agents with particular emphasis on structure activity relationships are reviewed. Graphical abstract: [Figure not available: see fulltext.]. © 2019, Springer Nature Switzerland AG.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :نیما رزاقی اصل
نویسنده :ساقی سپهری
نویسنده :احمد عبادی
نویسنده :پری کرمی
نویسنده :نگین نجات خواه
نویسنده :محمد جوهری اهر
Additional Information:IF(2018): 2.032 Indexing in: ISI, Pubmed/medline, Scopus, Index medicus
Uncontrolled Keywords:لیشمانیا، N-هتروسیکل، شیمی درمانی، لیشمانیا
کلیدواژه ها (انگلیسی):Leishmania, Chemotherapy, N-heterocycles, SAR
Subjects:QV pharmacology > QV 744 Medicinal Chemistry
Divisions:School of Pharmacy > Department of Medicinal Chemistry
ID Code:11948
Deposited By: ساقی سپهری
Deposited On:29 Mar 1398 11:44
Last Modified:02 Apr 1398 10:47

Repository Staff Only: item control page

Document Downloads

More statistics for this item...