ارتباط بین کمبود ویتامین دی و اختلالات رفتاری در بیماران sle

عنوان انگليسی

Relationship between Serum Vitamin D Level, Interferon Alpha and Psychological Disorders in Patients with SLE (Systemic Lupus Erythematosus

خلاصه انگلیسی

Background: In different studies, the correlation between systemic lupus erythematosus (SLE) and disease activity with vitamin D has been shown. Also, low level of vitamin D and interferon alpha was associated with psychological disorders but there wasn’t more evidence about the relationship between vitamin D deficiency and psychological disorders. Objective: This study aimed to investigate Relationship between serum vitamin D level, interferon alpha and psychological disorders in patients with SLE. Methods: In this cross-sectional descriptive study, 50 SLE patients were recruited. Serum 25-OH Vitamin D concentration and IFN-α levels and also, levels of SLEDAI were measured. Statistical methods were used to determine the correlation between vitamin D and IFN-α and also the correlation between INF-α with Depression, Stress and Anxiety scores in SLE patients. Results: Vitamin D deficiency (<40 nmol/L) was detected in 20% of SLE patients. The mean Vitamin D and INF-α in SLE patients was 23.94 ± 11.93 and 396.60 ± 54.73, respectively. There was significantly negative correlation between vitamin D and depression (r=-0.479, p=0.001) and Anxiety (r=-0.34, p=0.01) but the relation between vitamin D and stress wasn’t significant. Of all SLE patients, 56% had depression, 64% had anxiety and 66% had stress in very severe level. Conclusion: Results showed that the level of vitamin D was negatively correlated with depression and anxiety of patients. Also, it seems that, by increasing the QOL of patients and decreasing the rate of depression and anxiety in SLE patients we could improve the vitamin D level and then SLEDAI.

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