تجویز مرکزی آلیسکیرن به عنوان یک داروی مهار کننده رنین، عوارض سکته مغزی را مستقل از اثر کاهنده فشار آن بهبود می بخشد

پناهپور, حمداله and Terpolilli, Nicole and Schaffert, David and Culmsee, Carsten and Plesnila, Nikolaus (1398) تجویز مرکزی آلیسکیرن به عنوان یک داروی مهار کننده رنین، عوارض سکته مغزی را مستقل از اثر کاهنده فشار آن بهبود می بخشد. Frontiers in Neurology ــ 10 (942). pp. 1-11. شاپا 1664-2295


Official URL: https://www.frontiersin.org/articles/10.3389/fneur...


Central Application of Aliskiren, a Renin Inhibitor, Improves Outcome After Experimental Stroke Independent of Its Blood Pressure Lowering Effect

English Abstract

Epidemiological studies suggest that pharmacological reduction of systemic hypertension lowers incidence and severity of stroke. However, whether the reduction of blood pressure per se or the compounds used to reduce hypertension are responsible for this effect received little attention. In the current study we therefore aimed to investigate whether Aliskiren, a renin-inhibitor used to treat arterial hypertension, may improve outcome in a mouse model of ischemic stroke when applied centrally and in a dose not affecting blood pressure. Male C57BL/6 mice received 0.6, 2.0, or 6.0 µg Aliskiren or vehicle by intracerebroventricular injection as a pre-treatment and were then subjected to 60 min of middle cerebral artery occlusion (MCAo). Infarct volume, brain edema formation, mortality, antioxidant effects, and functional outcome were assessed up to seven days after MCAo. Central administration of Aliskiren (0.6 or 2.0 µg) had no effect on systemic blood pressure but significantly reduced infarct volume and brain edema formation, blunted mortality, and improved neurological outcome up to 1 week after MCAo. Due to the central and prophylactic administration of the compound, we cannot make any conclusions about the potency of Aliskiren for acute stroke treatment, however, our study clearly demonstrates, that in addition to lowering blood pressure Aliskiren seems to have a direct neuroprotective effect. Hence, renin-inhibitors may be an effective addition to prophylactic treatment regimens in stroke patients.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :حمداله پناهپور
نویسنده :Nicole Terpolilli
نویسنده :David Schaffert
نویسنده :Carsten Culmsee
نویسنده مسئول :Nikolaus Plesnila
Additional Information:IF: 2.635 Indexed in: ISI, Scopus, PubMed Central/PMC, Embase, DOAJ
کلیدواژه ها (انگلیسی):brain edema, focal Ischemia, neuroprotection, stroke, acute stroke, hypertension, experimental
Subjects:QT physiology
QV pharmacology
WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:12194
Deposited By: Dr Hamdollah Panahpour
Deposited On:01 Jul 1398 12:40
Last Modified:01 Jul 1398 12:44

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