تهیه و ارزیابی یک نانوحامل لیپوهیدروژلی نوین: رپاگلینید به عنوان یک داروی مدل لیپوفیل

ابراهیمی, حسینعلی and جوادزاده, یوسف and حمیدی, مهرداد and برزگر جلالی, محمد (1395) تهیه و ارزیابی یک نانوحامل لیپوهیدروژلی نوین: رپاگلینید به عنوان یک داروی مدل لیپوفیل. Journal of Pharmacy and Pharmacology ــ 68 (4). pp. 450-458. شاپا 2042-7158

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Official URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jp...


Development and characterization of a novel lipohydrogel nanocarrier: repaglinide as a lipophilic model drug

English Abstract

Objectives: Solid lipid nanoparticles (SLNs) are highly susceptible to phagocytosis by reticuloendothelial system (RES). To overcome this problem, a novel hydrogel-coated SLNs structure was developed and evaluated in this study. Methods: Solid lipid nanoparticles surface was coated with chitosan, via electrostatic attraction with the negatively charged SLNs surface. The resulting polymer-coated SLNs then hosted an inorganic poly-anionic agent, tripolyphosphate, to form the final lipohydrogel structure. Key findings: Compared with the bare SLNs, lipohydrogel nanoparticles (LHNs) showed a significant increase in size and zeta potential. The release profile showed lower burst release and lower release rate for LHNs compared with SLNs. LHNs nanoparticles released the model antidiabetic drug, repaglinide, in a more sustained manner with lower burst effect compared with the corresponding SLN structure. Cytotoxicity studies via cell culture and MTT assay revealed no bio-toxicity of the SLNs and LHNs. In addition, intravenous administration of repaglinide-loaded SLNs and LHNs in rats showed longer drug residence time in circulation for LHNs, a trend also evident for the blood glucose level-time profile. Conclusion: The particle size, zeta potential, FTIR and microscopy data demonstrated the formation of the supposed lipohydrogel nanoparticles. All these benefits of LHNs propose it as a promising candidate for controlled release of the drugs.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :حسینعلی ابراهیمی
نویسنده :یوسف جوادزاده
نویسنده مسئول :مهرداد حمیدی
نویسنده :محمد برزگر جلالی
Additional Information:IF: 2.405 Indexed in: ISI, Scopus, PubMed/Medline, Embase
کلیدواژه ها (انگلیسی):chitosan, lipohydrogel, nanocarrier, repaglinide, solid lipid nanoparticles
Subjects:QV pharmacology > QV 704 Pharmaceutics
QV pharmacology > QV 778 Pharmaceutical Nanotechnology
Divisions:School of Pharmacy > Department of Pharmaceutics
ID Code:12227
Deposited By: Dr Hossein Ali Ebrahimi
Deposited On:21 Jul 1398 15:55
Last Modified:21 Jul 1398 15:55

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