title

اثرات اضافه کردن پنتوکسیفیلین بر روی کاپتوپریل در پرفشاری خون اولیه "کارآزمایی بالینی تصادفی سازی شده پایلوت

نامدار, حسین and خانی, الناز and پوررشید, محمدحسن and انتظاری ملکی, طاهر (1398) اثرات اضافه کردن پنتوکسیفیلین بر روی کاپتوپریل در پرفشاری خون اولیه "کارآزمایی بالینی تصادفی سازی شده پایلوت. The Journal of Clinical Pharmacology ــ 1 (7). شاپا 0091-2700 (In Press)

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Title

Effects of Adding Pentoxifylline to Captopril on Primary Hypertension:A Pilot Randomized Clinical Trial

English Abstract

Because of the key role blood viscosity plays in the regulation of blood pressure (BP) and the hemorheological effects of pentoxifylline (PTX), this study was conducted to evaluate whether PTX can reduce BP when added to captopril in patients with stage 1 hypertension. In this randomized clinical trial 62 patients with stage 1 hypertension were entered. The intervention group (n = 30) received 1200 mg PTX in 3 divided doses plus 25 mg captopril 3 times a day, whereas the control group (n = 32) received only 75 mg captopril in 3 divided doses. Measurements of BP were done at baseline and in the first and second months after entering the study. Major adverse cardiac events during this period were recorded. When the systolic BP levels in the intervention and the control groups were compared, no significant differences at baseline (150.4 ± 6.03 versus 150.4 ± 6.2, P = .98) or first (138.4 ± 9.4 versus 142.3 ± 5.6, P = .08) or second (134.6 ± 8.9 versus 137.4 ± 6.0, P = .20) month of the study were noted. Similarly no significant difference was observed in the diastolic BP at baseline (91.7 ± 3.9 versus 92.0 ± 3.7, P = .84) or first (85.5 ± 5.1 versus 86.9 ± 3.8, P = .27) or second (82.6 ± 5.7 versus 84.0 ± 3.5, P = .31) month. Based on the results of present study, adding PTX as a hemorheological agent to captopril could not significantly reduce blood pressure in the patients with stage 1 hypertension.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :حسین نامدار
نویسنده :الناز خانی
نویسنده :محمدحسن پوررشید
نویسنده مسئول :طاهر انتظاری ملکی
Additional Information:IF: 2.915 Indexed in: ISI, Scopus, PubMed/Medline, Embase
کلیدواژه ها (انگلیسی):Blood pressure; captopril; major adverse cardiac events; pentoxifylline; primary hypertension; stage 1 hypertension
Subjects:QV pharmacology > QV 754 Clinical Pharmacy
QV pharmacology
WG Cardiovascular System
Divisions:School of Pharmacy > Department of Clinical Pharmacy
ID Code:12240
Deposited By: دکتر محمد حسن پوررشید
Deposited On:07 Jul 1398 12:57
Last Modified:07 Jul 1398 12:57

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