ریسک فاکتورهای مستعد کننده برای آدنوکارسینوم کاردیای معده

عبدی, عصمت and لطیفی نوید, سعید and زهری, صابر and یزدانبد, عباس and پورفرضی, فرهاد (1398) ریسک فاکتورهای مستعد کننده برای آدنوکارسینوم کاردیای معده. Cancer Medicine ــ 00 . pp. 1-13. شاپا 2045-7634 (In Press)

Text - Published Version

Official URL: https://onlinelibrary.wiley.com/doi/full/10.1002/c...


Risk factors predisposing to cardia gastric adenocarcinoma: Insights and new perspectives

English Abstract

Recent decades have seen an alarming increase in the incidence of cardia gastric adenocarcinoma (CGA) while noncardia gastric adenocarcinoma (NCGA) has decreased. In 2012, 260 000 CGA cases (age‐standardised rate (ASR); 3.3/100 000) and 691 000 NCGA cases (ASR; 8.8/100 000) were reported worldwide. Compared with women, men had greater rates for both the subsites, especially for CGA. Recently, four molecular subtypes of GC have been proposed by the Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG); however, these classifications do not take into account predisposing germline variants and their possible interaction with somatic alterations in carcinogenesis. The etiology of adenocarcinoma of the cardia and the gastroesophageal junction (GEJ) is not known. It is thought that CGA is distinct from adenocarcinomas located in the esophagus or distal stomach, both epidemiologically and biologically. Moreover, CGA is often identified in the advanced stage having a poor prognosis. Therefore, understanding the risk and the role of predisposing factors in etiology of CGA can inform clinical practice and counseling for risk reduction. In this paper, we showed that GC family history, lifestyle, demographics, gastroesophageal reflux disease, Helicobacter pylori infection, and multiple genetic and epigenetic risk factors as well as several predisposing conditions may underlie susceptibility to CGA. However, several genome‐wide association studies (GWASs) should be conducted to identify novel high‐penetrance genes and pathways as well as causal germline variants predisposing to CGA. They must include different ethnic groups, especially from high‐incidence countries for CGA, because some risk loci are ancestry‐specific. In parallel, statistical methods can be developed to identify cancer predisposition genes (CPGs) from tumor sequencing data. It is also necessary to find novel long noncoding RNAs related to the risk of CGA. Taken altogether, new cancer risk prediction models, including all genetic and nongenetic factors influencing risk, should be developed to facilitate risk assessment, disease prevention, and early diagnosis and intervention of CGA in the future.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :عصمت عبدی
نویسنده مسئول :سعید لطیفی نوید
نویسنده :صابر زهری
نویسنده :عباس یزدانبد
نویسنده :فرهاد پورفرضی
Additional Information:IF:3.357 Indexed in: ISI, PubMed/Medline, Scopus, Embase, DOAJ
کلیدواژه ها (انگلیسی):Helicobacter pylori ; cardia gastric adenocarcinoma; risk biomarkers
Subjects:WI Digestive System
Divisions:Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:12267
Deposited By: Dr Abbas Yazdanbod
Deposited On:13 Jul 1398 13:24
Last Modified:13 Jul 1398 13:24

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