مهار آنزیم تبدیل کننده آنژیوتانسین مرکزی توسط انالاپریل مغز را در برابر آسیب ناشی از ایسکمی در موش صحرایی با فشار خون طبیعی محافظت می کند

پناهپور, حمداله and دهقان, غلامعباس (1388) مهار آنزیم تبدیل کننده آنژیوتانسین مرکزی توسط انالاپریل مغز را در برابر آسیب ناشی از ایسکمی در موش صحرایی با فشار خون طبیعی محافظت می کند. Daru ــ 18 (1). pp. 35-40. شاپا ISSN: 1560-8115

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Inhibition of central angiotensin-converting enzyme with enalapril protects the brain from ischemia/reperfusion injury in normotensive rat

English Abstract

Background and the Purpose of the study: Central Angiotensin Converting Enzyme (ACE) has an important role on cerebral microcirculation and metabolism. However, its role in terms of protecting the brain from ischemic/reperfusion (I/R) injury are debatable. This study evaluated the role of ACE, using enalapril as ACE inhibitor, in protection of the brain from I/R injury during transient focal cerebral ischemia (TFCI) in normotensive rat. Method: Male Sprague Dawley rats (280-320g) randomly assigned to control ischemic and enalapril pre-treated ischemic groups. Enalapril was injected intraperitoneally 1 h before middle cerebral artery occlusion (MCAO) at the dose of 0.03 or 0.1 mg/kg. Cerebral ischemia was induced by 60 min MCAO followed by 24 hrs reperfusion. After evaluation of neurological deficit scores (NDS) the animal was sacrificed for assessment of cerebral infarction and edema. Results: TFCI induced cerebral infarctions (283±18 mm3), brain edema (4.1±0.4%) and swelling (9.8±1.5%) with NDS of 3.11±0.36. Non-hypotensive dose of enalapril (0.03 mg/kg) improved NDS (1.37±0.26), reduced cerebral infarction (45%), brain edema (54%) and swelling of the lesioned hemispheres (34%) significantly. However, hypotensive dose of enalapril (0.1 mg/kg) could improve neurological activity (1.67±0.31) and failed to reduce cerebral infarction (276±39mm3) and swelling (10.4±1.4%). Conclusion: In the rat model of transient focal cerebral ischemia, inhibition of angiotensin converting enzyme with non-hypotensive doses of enalapril has the benefit of improving neurological activity, reducing cerebral infarction, brain swelling and edema of acute ischemic stroke. Therefore, it is reasonable to conclude that central renin-angiotensin system may participate in ischemic/reperfusion injury of the cerebral cortex.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :حمداله پناهپور
نویسنده مسئول :غلامعباس دهقان
Additional Information:cited By (since 1996) 0 indexed and abstracted :1-ISI, 2- Scopus,Chemical Abstracts Service (CAS , Excerpta Medica/EMBASE, Biological Abstracts (BIOSIS) 3- world-known bibliographical databases including ), International Pharmaceutical Abstracts (IPA), Index Medicus for WHO Eastern Mediterranean Region (IMEMR), Natural Product Extracts (NAPRALERT), CAB Abstracts, Index Copernicus, Global Health, Journal List and EBSCO
کلیدواژه ها (انگلیسی):Cerebral ischemia, Lesion volume, Edema, ACE inhibition, Enalapril
Subjects:WL Nervous system
WG Cardiovascular System
QT physiology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:1236
Deposited By: Dr Hamdollah Panahpour
Deposited On:14 Feb 1389 08:23
Last Modified:15 Nov 1391 14:37

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