آموزش در فاصله های زمانی یادگیری را در موش های مدل Ts65Dn و Ube3a ناتوانی فکری بهبود می بخشد

Lauterborn, J. C. and Schultz, M. N. and Le, A. A. and امانی, محمد and Friedman, A. E. and Leach, P. T. and Gall, C. M. and Lynch, G. S. and Crawley, J. N. (1398) آموزش در فاصله های زمانی یادگیری را در موش های مدل Ts65Dn و Ube3a ناتوانی فکری بهبود می بخشد. Translational Psychiatry ــ 9 (166). pp. 1-16. شاپا 2158-3188

Text - Published Version

Official URL: https://www.nature.com/articles/s41398-019-0495-5#...


Spaced training improves learning in Ts65Dn and Ube3a mouse models of intellectual disabilities

English Abstract

Benefits of distributed learning strategies have been extensively described in the human literature, but minimally investigated in intellectual disability syndromes. We tested the hypothesis that training trials spaced apart in time could improve learning in two distinct genetic mouse models of neurodevelopmental disorders characterized by intellectual impairments. As compared to training with massed trials, spaced training significantly improved learning in both the Ts65Dn trisomy mouse model of Down syndrome and the maternally inherited Ube3a mutant mouse model of Angelman syndrome. Spacing the training trials at 1 h intervals accelerated acquisition of three cognitive tasks by Ts65Dn mice: (1) object location memory, (2) novel object recognition, (3) water maze spatial learning. Further, (4) spaced training improved water maze spatial learning by Ube3a mice. In contrast, (5) cerebellar-mediated rotarod motor learning was not improved by spaced training. Corroborations in three assays, conducted in two model systems, replicated within and across two laboratories, confirm the strength of the findings. Our results indicate strong translational relevance of a behavioral intervention strategy for improving the standard of care in treating the learning difficulties that are characteristic and clinically intractable features of many neurodevelopmental disorders.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :J. C. Lauterborn
نویسنده :M. N. Schultz
نویسنده :A. A. Le
نویسنده :محمد امانی
نویسنده :A. E. Friedman
نویسنده :P. T. Leach
نویسنده :C. M. Gall
نویسنده :G. S. Lynch
نویسنده مسئول :J. N. Crawley
Additional Information:IF: 5.182 Indexed in:ISI, Scopus, PubMed/Medline, Embase, DOAJ
کلیدواژه ها (انگلیسی):Ts65Dn, Ube3a, disabilities , location memory
Subjects:QT physiology
WM Psychiatry
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:12393
Deposited By: Dr Hamid Sheikhkanloui Milan
Deposited On:20 Aug 1398 10:53
Last Modified:20 Aug 1398 10:53

Repository Staff Only: item control page

Document Downloads

More statistics for this item...