title

پیریدین-2،3-دی کربوکسیلات ، اسید quinolinic ، باعث تجمع آمیلوئید 1N4R تاو در شرایط آزمایشگاهی می شود: شواهد دیگری برای اثرات مخرب و اجتناب ناپذیر نوروتوکسین درون زا

اسماعیلی, سجاد and قبادی, نازنین and اکبری, ولی and مرادی, سجاد and شهلائی, محسن and قبادی, سیروس and جلالوند, علیرضا and امانی, مجتبی and خدارحمی, رضا (1398) پیریدین-2،3-دی کربوکسیلات ، اسید quinolinic ، باعث تجمع آمیلوئید 1N4R تاو در شرایط آزمایشگاهی می شود: شواهد دیگری برای اثرات مخرب و اجتناب ناپذیر نوروتوکسین درون زا. Chemico-Biological Interactions ــ 315 . p. 108884. شاپا 1872-7786

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Title

Pyridine-2,3-dicarboxylate, quinolinic acid, induces 1N4R Tau amyloid aggregation in vitro: Another evidence for the detrimental effect of the inescapable endogenous neurotoxin

English Abstract

Quinolinic acid (QA) known as a neuro-active metabolite associated with the kynurenine pathway. At high concentrations, QA is often involved in the initiation and development of several human neurologic diseases, like Alzheimer's disease. Because of the QA action as the NMDA receptor, it is considered as a potent excitotoxin in vivo. Since it is probable that different mechanisms are employed by QA, activation of NMDA receptors cannot fully explain the revealed toxicity and it is even believed that there are multiple unknown mechanisms/targets leading to QA cytotoxicity. Herein we report accelerated amyloid oligomerization of 1N4R Tau under the effect of QA, in vitro, then the molecular structure, morphology and toxicity of the protein aggregate were documented by using various theoretical/experimental approaches. The possible mechanism of action of QA-induced Tau oligomerization has also been explored.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :سجاد اسماعیلی
نویسنده :نازنین قبادی
نویسنده :ولی اکبری
نویسنده :سجاد مرادی
نویسنده :محسن شهلائی
نویسنده :سیروس قبادی
نویسنده :علیرضا جلالوند
نویسنده :مجتبی امانی
نویسنده مسئول :رضا خدارحمی
Additional Information:IF: 3.407 Indexed in: ISI, PubMed/Medline, Scopus, Embase
Uncontrolled Keywords:Quinolinic acid, Tau, Amyloid aggregation, Binding, Toxicity mechanism
Subjects:QV pharmacology > QV 744 Medicinal Chemistry
QU Biochemistry
Divisions:School of Pharmacy > Department of Medicinal Chemistry
ID Code:12410
Deposited By: Dr Mojtaba Amani
Deposited On:11 Sep 1398 13:34
Last Modified:11 Sep 1398 13:34

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