title

تأثیر اسید لینوئلیک کونژوکه بر استرس اکسیداتیو و متالوپروتئینازهای 2 و 9 در بیماران مبتلا به COPD

متین, سمیه and قبادی مراللو, حسن and نعمتی, علی and علی پناه مقدم, رضا and رضاقلی زاده, لطف اله and جوادی, حسن (1398) تأثیر اسید لینوئلیک کونژوکه بر استرس اکسیداتیو و متالوپروتئینازهای 2 و 9 در بیماران مبتلا به COPD. در: CHEST Regional Congress 2019 Athens, 27-29 JUNE, Athens, Greece.

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Official URL: https://journal.chestnet.org/article/S0012-3692(19...


Title

THE EFFECT OF CONJUGATED LINOLEIC ACID ON OXIDATIVE STRESS AND MATRIX METALLOPROTEINASES 2 AND 9 IN PATIENTS WITH COPD

English Abstract

PURPOSE:Natural antioxidants in foods may be used in prevention and treatment of oxidative stress and inflammation inCOPD. Therefore, this study aimed to evaluate the effect of conjugated linoleic acid (CLA) supplement as natural antioxidants onoxidative stress levels, and MMP2 and MMP9 serum levels in COPD patients.METHODS:This clinical trial study was conducted on 90 (supplement and control group) COPD patients. After obtainingwritten consent, general information was collected from each patient using a validated and reliable questionnaire. Supplementgroup received 3.2 g of CLA and those in the control group were given 3.2 g of placebo for 6 weeks on a daily basis.Fasting bloodsamples were taken from all of the patients for testing of malondialdehyde, MMP2 and MMP9 levels at the beginning and end ofthe study.RESULTS:There were no significant differences between the two groups with regard to mean age, smoking status, and serumlevel of MDA at the beginning of the study. In the supplement group, the serum level of MDA decreased significantly at the end ofthe 6th week compared to that in the beginning of the study (p¼0.0004), while in the placebo group, the difference was found tobe insignificant. The serum level of MMP9 decreased significantly in the supplement group, while in the placebo group its levelincreased significantly as compared to that at the beginning of the study (p,0.05)CONCLUSIONS:that CLA supplementation may be helpful for COPD patients through inhibiting the production of oxidativestress and controlling MMP9 serum levels

Item Type:Conference or Workshop Item (Speech)
زبان سند : انگلیسی
نویسنده اول :سمیه متین
نویسنده مسئول :حسن قبادی مراللو
نویسنده :علی نعمتی
نویسنده :رضا علی پناه مقدم
نویسنده :لطف اله رضاقلی زاده
نویسنده :حسن جوادی
کلیدواژه ها (انگلیسی):COPD, CLA, oxidative stress, MMP2, MMP9
Subjects:QU Biochemistry
WD Nutrition Disease and metabolic diseases
WF Respiratory System
Divisions:Faculty of Medicine > research unit > completed research projects
ID Code:12420
Deposited By: دکتر سمیه متین
Deposited On:20 Aug 1398 13:44
Last Modified:11 Feb 1399 08:27

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