تاثیر ورزش بر سطوح سیتوکین های التهابی در زنان منوپوز-مطالعه کنترل شده تصادفی

ترتیبیان, بختیار and FitzGerald, LZ and آزادپور, نوشین and حاجی زاده مالکی, بهزاد (1394) تاثیر ورزش بر سطوح سیتوکین های التهابی در زنان منوپوز-مطالعه کنترل شده تصادفی. Post Reproductive Health ــ 21 (1). pp. 9-15. شاپا 2053-3691, 2053-3705

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Official URL: https://journals.sagepub.com/doi/full/10.1177/2053...


A randomized controlled study examining the effect of exercise on inflammatory cytokine levels in post-menopausal women

English Abstract

BACKGROUND: Elevated plasma levels of inflammatory cytokine are associated with body mass index, percent body fat and increased morbidity. Evidence suggests that higher levels of physical activity result in beneficial anti-inflammatory effects compared to a more sedentary lifestyle. Further, reproductive hormones are associated with inflammaotry cytokines. This study examined the effect of a 16-week low-moderate intensity exercise (EX) programme on reproductive hormones and inflammatory cytokines. METHODS: Twenty-eight healthy, sedentary post-menopausal women were randomly assigned to EX (n = 14) or control (Con, n = 14) groups. The EX group completed low-moderate intensity treadmill training 25-30 min/day, up to 55% of HRmax, 3-4 days/week, for 16-weeks. Con maintained current physical activity level. Baseline and week-16 serum samples evaluated interleukin-1 beta, interleukin-6, tumor necrosis factor-alpha, C-reactive protein, estradiol, luteinizing hormone and follicular stimulating hormone. RESULTS: Post-intervention, the EX group showed a significant decrease in interleukin-1 beta, interleukin-6, tumor necrosis factor-alpha, estradiol, follicular stimulating hormone and luteinizing hormone levels compared to baseline values. No significant changes were observed in Con. Significant correlations were observed between IL-1β, IL-6, TNF-α, and reproductive hormones, both before and after the exercise intervention. CONCLUSION: Findings suggest that a low-moderate intensity EX programme decreases cytokines in relation to reproductive hormones in post-menopausal women. These findings support the role of EX in reducing inflammatory markers and improved reproductive hormones in post-menopausal women.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :بختیار ترتیبیان
نویسنده مسئول :LZ FitzGerald
نویسنده :نوشین آزادپور
نویسنده :بهزاد حاجی زاده مالکی
Additional Information:Indexed in: PubMed/Medline, Scopus, Embase
کلیدواژه ها (انگلیسی):Cytokines; hot flushes; menopause; moderate exercise; sex hormones
Subjects:QT physiology
WP Gynecology
ID Code:12509
Deposited By: خانم نوشین آزادپور
Deposited On:07 Oct 1398 09:05
Last Modified:07 Oct 1398 09:05

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