title

بابونه گاوی آسیب های بیضوی القا شده با تتراکلریدکربن در موش های صحرایی را کم می کند

مأذنی, محمد and بنایی, شکوفه and رضاقلی زاده, لطف اله (1398) بابونه گاوی آسیب های بیضوی القا شده با تتراکلریدکربن در موش های صحرایی را کم می کند. Journal of Herbmed Pharmacology ــ 9 (1). pp. 42-47. شاپا 2345-5004

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Title

Feverfew attenuates carbon tetrachloride-induced testicular damage in rats

English Abstract

Introduction: Feverfew is an herbal medicine with a traditional usage of treating several disorders. Some investigations have demonstrated that feverfew is an effective remedy for the prophylactic treatment of inflammatory conditions, migraine and menstrual disorders. Therefore, this study was arranged out to evaluate the protective or curative potentials of feverfew methanolic extract (FME) on carbon tetrachloride (CCl4) induced oxidative trauma in testis. Methods: In this experiment, male Wistar rats were divided into seven groups (n=6). Group I as a normal control received 1 mL/kg distilled water for 14 days orally and on the 14th day olive oil (1.5 mL/kg, i.p.). Group II received 1 mL/kg distilled water orally for 14 consecutive days. Groups III, IV and V animals were pretreatment groups and treated with three different doses of FME (40, 80, and 120 mg/kg, p.o, respectively) for 14 days. All groups except group one, were also intoxicated with 1.5 ml CCl4 (i.p, in a 1:1 dilution with olive oil) on the 14th day. Groups VI and VII were post-treatment groups and received FME (80 and 120 mg/kg, p.o, respectively) at 2, 6, 24 and 48 h after CCl4 injection. Results: Injection of CCl4 significantly (P < 0.001) reduced antioxidant enzymes (SOD and GPx) and increased malondialdehyde when compared to the control group. Administration of FME significantly (P < 0.05) improved these alterations near to control rats. Conclusion: It is suggested that FME has the ability to protect testis against oxidative damage, possibly through antioxidant effects of its bioactive compounds.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :محمد مأذنی
نویسنده :شکوفه بنایی
نویسنده مسئول :لطف اله رضاقلی زاده
Additional Information:Indexed in: Scopus, Embase, DOAJ
Uncontrolled Keywords:بابونه گاوی، تتراکلرید کربن، آسیب بیضوی، آنتی اکسیدان، موش صحرایی
کلیدواژه ها (انگلیسی):Feverfew, Carbon tetrachloride, Testicular damage, Antioxidant, Rat
Subjects:QU Biochemistry
QV pharmacology > QV 766 Plants, Medicinal
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Biochemistry
ID Code:12610
Deposited By: Dr Mohammad Mazani
Deposited On:25 Oct 1398 13:31
Last Modified:25 Oct 1398 13:32

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