کاربرد نانوذرات در درمان عفونتهای ویروسی و ملاحظات سم شناسی

فصیلی, زهره and ابراهیمی, حسینعلی and محمدخانلو, الهام and کهریزی, فرزاد and مهری, فرشته and سلیمی, احمد (1398) کاربرد نانوذرات در درمان عفونتهای ویروسی و ملاحظات سم شناسی. Pharmaceutical and Biomedical Research ــ 5 (4). pp. 1-20. شاپا 2423-4494

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Applying Nanoparticles in the Treatment of Viral Infections and Toxicological Considerations

English Abstract

Background: Despite the tremendous progress in human medicine, viral infections can cause death in them. Due to the high prevalence of viruses, it is required to develop novel treatment strategies and provide the site-specific delivery of antiviral agents at the viral reservoirs. Objectives: Particle size is a vital physical characteristic that can affect the bioavailability and circulation time of nanoparticles. The ratio of large surface area and volume of nanoparticle could enhance the solubility of poorly soluble drug compounds. Methods: Therefore, the optimum surface charge of the nanoparticle with the possibility of encapsulation and large drug cargo, are some of the nanoformulation advantages of these agents. Results: This study reviewed various nanocarriers and modern smart delivery technologies, such as liposomes and immunoliposomes, polymeric nanoparticles, nanoemulsions, nanosuspensions, dendrimers, solid lipid nanoparticles, and so on. Conclusion: We aimed to overcome the problems of traditional formulations and resistance to currently available therapies in various infections. Moreover, the concerns about the potential toxicities of nanoparticles to humans have been raised; therefore, the present study has reviewed the toxicity effects of nanoparticles used in controlling viral infections.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :زهره فصیلی
نویسنده :حسینعلی ابراهیمی
نویسنده :الهام محمدخانلو
نویسنده :فرزاد کهریزی
نویسنده مسئول :فرشته مهری
نویسنده مسئول :احمد سلیمی
Additional Information:Indexed in: DOAJ , Google Scholar, ISC, SID , Magiran
کلیدواژه ها (انگلیسی):Nanoparticles, Drug delivery, Nanomedicine, Toxicity, Antiviral
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology > QV 778 Pharmaceutical Nanotechnology
Divisions:School of Pharmacy > Department of Pharmaceutics
School of Pharmacy > Department of Toxicology
ID Code:12666
Deposited By: Dr Hossein Ali Ebrahimi
Deposited On:12 Nov 1398 10:43
Last Modified:24 Jan 1401 08:24

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  • کاربرد نانوذرات در درمان عفونتهای ویروسی و ملاحظات سم شناسی. (deposited 12 Nov 1398 10:43) [Currently Displayed]

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