اثر محافظتی استروژن بر سمیت القا شده با تری بوتیل تین در جزایر لانگرهانس موش صحرایی

قائم ملکی, فائزه and محمدی, پرهام سعداله and بعیری, مریم and نوایی نیگجه, مونا and عبدالهی, محمد and مصطفی لو, سارا (1398) اثر محافظتی استروژن بر سمیت القا شده با تری بوتیل تین در جزایر لانگرهانس موش صحرایی. Heliyon ــ 6 (3). e03562. شاپا 2405-8440

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Estrogens counteract tributyltin-induced toxicity in the rat islets of Langerhans

English Abstract

Background Tributyltin (TBT) is known as an endocrine disruptor able to interfere with estrogen receptors (ERs) leading to toxic effects on the related endocrine pathways. TBT is an obesogen, reported to disrupt glucose homeostasis leading to diabetes. The aim of this study was to assess the influence of TBT and β-estradiol on the pancreatic islets of Langerhans in simultaneous exposures. Experimental Pancreatic islets of 15 male rat were isolated and exposed to TBT (10 μM), β-estradiol, and TBT plus β-estradiol for 24 h. Therewith, cellular viability, oxidative stress, apoptosis, and insulin secretion markers were investigated. Results TBT decreased the viability and increased the apoptosis, reactive oxygen species, and insulin secretion TBT led to increased amounts of apaptosis, reactive oxygen species (ROS), and insulin secretion in pancreatic islets; however, cellular viability was reduced. Co-exposure with β-estradiol ameliorated the entire mentioned variables near to the control level. Conclusion These results showed that β-estradiol protect pancreatic islets of Langerhans against TBT-induced toxicity by counteracting oxidative stress and apoptosis as well as insulin secretion. In this way, it is postulated that pancreatic ER pathways particularly in β-cells might be the determinant target of toxic effects of xenoestrogens like TBT. Hence, evaluation of xenoestrogens-induced ER dysfunction in the endocrine pancreas can be helpful in diabetic risk assessment of these contaminants. Pharmacological modifications of ER pathway in the β-cells seems promising for better management of diabetes.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :فائزه قائم ملکی
نویسنده :پرهام سعداله محمدی
نویسنده :مریم بعیری
نویسنده :مونا نوایی نیگجه
نویسنده :محمد عبدالهی
نویسنده مسئول :سارا مصطفی لو
Additional Information:Indexed in: Scopus, PubMed/PMC, ESCI, DOAJ
کلیدواژه ها (انگلیسی):tributyltin, estrogen, pancreas, diabetes
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Pharmacology
School of Pharmacy > Department of Toxicology
ID Code:12749
Deposited By: Dr Sara Mostafalou
Deposited On:20 Dec 1398 09:47
Last Modified:20 Dec 1398 09:55

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