هاشمی, رضا ، حسینی اصل, سید سعید ، عارف حسینی, رفیع ، مرشدی, محمد (1399) تاثیر جذب ویتامین دی سه بر مارکرهای التهابی در بیماران مبتلا به مولتیپل اسکلروزیس و بستگان درجه یک ایشان. PloS ONE ــ 15 (4). ص.ص.1-17. شاپا 1932-6203
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آدرس اینترنتی رسمی : https://journals.plos.org/plosone/article?id=10.13...
عنوان انگليسی
The impact of vitamin D3 intake on inflammatory markers in multiple sclerosis patients and their first-degree relatives
خلاصه انگلیسی
Background & aims In our previous study, a Seesaw model was proposed for the fluctuation of crucial anti- (IL-10) and pro-inflammatory (Il-6 & IL-17A) cytokines through vitamin D3. In this paper, however, it is intended to extend the mentioned model by assessing the expression mRNA levels of IL-27 and TGF-β1 as well as the changes of plasma levels of IL-27, TGF-β1, IL-17A, IL-10, and IL-6 after treatment by vitamin D3. Method Venous blood samples were drawn from Healthy Participants (HP, n = 25) and First-Degree Relative Participants (FDRP, n = 25) as control groups and Multiple Sclerosis Participants (MSP, n = 25) before and after eight weeks of supplementation with 50000 IU vitamin D3. The mRNA expression and plasma concentrations were gauged by using Real-Time PCR and ELISA assay, respectively. Results The mRNA surfaces of IL-27, as well as TGF-β1, were up-regulated. However, the plasma levels of TGF-β1, IL-17A, and IL-6 were significantly different among the three groups. In addition, the plasma levels of IL-27, TGF-β1, IL-10, IL-17A, and IL-6 significantly changed following the administration of vitamin D3. Conclusion The findings of this paper illustrate that anti-inflammatory cytokines could have a key role in immunomodulatory functions due to their anti-inflammatory functions. To conclude, this might contribute to preventing the pathophysiological process of MS. Also, the proposed model could be used as a preventive way on disposed people to multiple sclerosis, particularly in first degree relatives of these patients.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده مسئول : | رضا هاشمی |
نویسنده : | سید سعید حسینی اصل |
نویسنده : | رفیع عارف حسینی |
نویسنده : | محمد مرشدی |
ضریب تاثیر و نمایه مجلات: | IF:2.776 Indexed in: ISI, Scopus, PubMed, Embase, DOAJ |
کلیدواژه ها (انگلیسی): | vitamin D3 ,multiple sclerosis ,inflammatory |
موضوعات : | WL سیستم عصبی |
بخش های دانشگاهی : | دانشكده پزشكي > گروه علوم پایه > بخش ژنتیک |
کد شناسایی : | 12828 |
ارائه شده توسط : | دکتر سید سعید حسینی اصل |
ارائه شده در تاریخ : | 23 فروردین 1399 13:47 |
آخرین تغییر : | 23 فروردین 1399 13:47 |
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