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تاثیر جذب ویتامین دی سه بر مارکرهای التهابی در بیماران مبتلا به مولتیپل اسکلروزیس و بستگان درجه یک ایشان

هاشمی, رضا ، حسینی اصل, سید سعید ، عارف حسینی, رفیع ، مرشدی, محمد (1399) تاثیر جذب ویتامین دی سه بر مارکرهای التهابی در بیماران مبتلا به مولتیپل اسکلروزیس و بستگان درجه یک ایشان. PloS ONE ــ 15 (4). ص.ص.1-17. شاپا 1932-6203

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عنوان انگليسی

The impact of vitamin D3 intake on inflammatory markers in multiple sclerosis patients and their first-degree relatives

خلاصه انگلیسی

Background & aims In our previous study, a Seesaw model was proposed for the fluctuation of crucial anti- (IL-10) and pro-inflammatory (Il-6 & IL-17A) cytokines through vitamin D3. In this paper, however, it is intended to extend the mentioned model by assessing the expression mRNA levels of IL-27 and TGF-β1 as well as the changes of plasma levels of IL-27, TGF-β1, IL-17A, IL-10, and IL-6 after treatment by vitamin D3. Method Venous blood samples were drawn from Healthy Participants (HP, n = 25) and First-Degree Relative Participants (FDRP, n = 25) as control groups and Multiple Sclerosis Participants (MSP, n = 25) before and after eight weeks of supplementation with 50000 IU vitamin D3. The mRNA expression and plasma concentrations were gauged by using Real-Time PCR and ELISA assay, respectively. Results The mRNA surfaces of IL-27, as well as TGF-β1, were up-regulated. However, the plasma levels of TGF-β1, IL-17A, and IL-6 were significantly different among the three groups. In addition, the plasma levels of IL-27, TGF-β1, IL-10, IL-17A, and IL-6 significantly changed following the administration of vitamin D3. Conclusion The findings of this paper illustrate that anti-inflammatory cytokines could have a key role in immunomodulatory functions due to their anti-inflammatory functions. To conclude, this might contribute to preventing the pathophysiological process of MS. Also, the proposed model could be used as a preventive way on disposed people to multiple sclerosis, particularly in first degree relatives of these patients.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده مسئول :رضا هاشمی
نویسنده :سید سعید حسینی اصل
نویسنده :رفیع عارف حسینی
نویسنده :محمد مرشدی
ضریب تاثیر و نمایه مجلات:IF:2.776 Indexed in: ISI, Scopus, PubMed, Embase, DOAJ
کلیدواژه ها (انگلیسی):vitamin D3 ,multiple sclerosis ,inflammatory
موضوعات :WL سیستم عصبی
بخش های دانشگاهی :دانشكده پزشكي > گروه علوم پایه > بخش ژنتیک
کد شناسایی :12828
ارائه شده توسط : دکتر سید سعید حسینی اصل
ارائه شده در تاریخ :23 فروردین 1399 13:47
آخرین تغییر :23 فروردین 1399 13:47

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