title

سرطان مدولاري تیرویید با سطح سرمی بالای ویتامین D و پلی مورفیسم هاي گیرنده آن مرتبط است

رمضانی, مهرنوش ، مأذنی, محمد ، طباطبایی, معراج ، رحیمیان, علی ، مسافری, الناز ، هدایتی, مهدی (1399) سرطان مدولاري تیرویید با سطح سرمی بالای ویتامین D و پلی مورفیسم هاي گیرنده آن مرتبط است. Physiology International ــ 220 (11). ص.ص.1-14. شاپا 2498-602X

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عنوان انگليسی

Medullary thyroid cancer is associated with high serum vitamin D level and polymorphism of vitamin D receptors

خلاصه انگلیسی

Background: Thyroid cancer is the most common endocrine malignancy. Studies have observed an anticancer effect for vitamin D and found that polymorphisms of vitamin D receptors can influence the prevalence of various cancers. The present study investigated the serum level of vitamin D and FokI, BsmI and Tru9I polymorphisms of vitamin D receptors. Methods: Forty patients with medullary thyroid cancer and 40 healthy controls were investigated. The genomic DNA of the subjects was extracted using saturated salt/proteinase K and investigated by PCR sequencing. Serum levels of vitamin D were evaluated by ELISA. The results were analyzed in SPSS and GraphPad Prism 5 software. Results: The genotypic and allelic frequencies of FokI and BsmI polymorphisms showed no significant differences between test and control groups. For Tru9I polymorphism, Tt genotype and t allelic frequency in the test group were significantly different from those of the control group. Also, we found Tt genotype and t allelic frequency to be significantly associated with medullary thyroid cancer (MTC) type and the aggressiveness of the disease. The average serum vitamin D level was 23.32 ng/mL and 18.95 ng/mL for patients and controls, respectively, and the difference between the two groups was statistically significant. Moreover, we found high serum vitamin D level to be associated with t allelic frequency. Conclusions: Unexpectedly, the mean serum vitamin D level of the test group was significantly higher than that of the control group. Tru9I polymorphism was found to be significantly correlated with the prevalence of medullary thyroid carcinoma.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :مهرنوش رمضانی
نویسنده :محمد مأذنی
نویسنده :معراج طباطبایی
نویسنده :علی رحیمیان
نویسنده :الناز مسافری
نویسنده مسئول :مهدی هدایتی
ضریب تاثیر و نمایه مجلات:Impact Factor (2018): 1.113 Indexed in: ISI, Scopus, PubMed, Embase
کلیدواژه ها (انگلیسی):medullary thyroid carcinoma; vitamin D; vitamin D receptor; polymorphism
موضوعات :QU بیوشیمی
WK سیستم غدد
بخش های دانشگاهی :دانشكده پزشكي > گروه علوم پایه > بخش بیوشیمی
کد شناسایی :12859
ارائه شده توسط : دکتر محمد مأذنی
ارائه شده در تاریخ :31 فروردین 1399 23:43
آخرین تغییر :31 فروردین 1399 23:43

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