بررسی اثر فنوباربیتال،فنی توئین،کاربامازپین،توپیرامات و سدیم والپروات بر سرعت انتقال عصبی در کودکان تحت درمان ضد تشنج

احمدآبادی, فرزاد and فتاح زاده اردلانی, قاسم and عطالو, ابوالفضل and بدیهی, پوریا (1398) بررسی اثر فنوباربیتال،فنی توئین،کاربامازپین،توپیرامات و سدیم والپروات بر سرعت انتقال عصبی در کودکان تحت درمان ضد تشنج. international journal of neurology and neurotherapy ــ 6 (2). شاپا 2378-3001

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Official URL: https://www.clinmedjournals.org/articles/ijnn/inte...


Investigating the Effects of Phenytoin, Phenobarbital, Topiramate, Carbamazepine and Sodium Valproate on the Neurotransmitter Speed in Treated Seizure Children

English Abstract

Anticonvulsants such as phenytoin, phenobarbital, topiramate, carbamazepine and valproate due to their beneficial effects and economic benefits in compare to new drugs are used more but these drugs are not harmless and sometimes had dangerous, safe and reversible side effects. Reduction of the nervous conduction velocity (NCV) is the common side effect of these drugs and it is of clinically importance if it is severe especially in treated children. Therefore, it is necessary to evaluate and compare the effect of each drug on NCV. The aim of this study was to investigate the effects of antiepileptic drugs on NCV. In this quasi-experimental study, 125 children with seizure were randomly selected and divided into six equal size groups which received phenytoin, phenobarbital, topiramate, valproate, carbamazepine and one group as control which no received anti-epileptic drug. Sensory and motor neural conduction velocity were measured and recorded for all children in groups. Collected data were analyzed by statistical methods in SPSS version 19. All of anticonvulsants were reduced the NCV in children but among all drugs, phenobarbital and phenytoin had the least and most impact on the NCV. The changes in NCV were not related to the age and gender of children. Results showed that the anticonvulsants had similar impact on NCV in generally but future studies are recommended by considering the other effective variables on response to drug.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :فرزاد احمدآبادی
نویسنده :قاسم فتاح زاده اردلانی
نویسنده مسئول :ابوالفضل عطالو
دانشجو :پوریا بدیهی
کلیدواژه ها (انگلیسی):Seizure, Anticonvulsants, Nerve conduction velocity (NCV), Epilepsy
Subjects:QV pharmacology > QV 754 Clinical Pharmacy
QV pharmacology
WL Nervous system
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
ID Code:12993
Deposited By: Dr Farzad Ahmadabadi
Deposited On:25 Mar 1399 08:48
Last Modified:25 Mar 1399 08:48

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