اثر حفاظتی عصاره هیدروالکلی دارچین و زنجبیل بر آسیب بیضه ای القا شده با تتراکلرید کربن در موش صحرایی

مأذنی, محمد and اوجارودی, معسود and بنایی, شکوفه and سلیم نژاد, رامین and لطیفی, میلاد and عزیزی, هانیه and رضاقلی زاده, لطف اله (1399) اثر حفاظتی عصاره هیدروالکلی دارچین و زنجبیل بر آسیب بیضه ای القا شده با تتراکلرید کربن در موش صحرایی. Andrologia ــ 10 (1111). pp. 1-9. شاپا 1439-0272

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Official URL: https://onlinelibrary.wiley.com/journal/14390272


The protective effect of cinnamon and ginger hydro‐alcoholic extract on carbon tetrachloride‐induced testicular damage in rats

English Abstract

Sexual dysfunction of men is one of the most serious problems in human society. This study aimed to evaluate the protective effect of cinnamon and ginger extract on testicular damages induced by carbon tetrachloride (CCl4). Thirty‐six male Wistar rats were randomly divided into 6 groups (n = 6): 1. Normal control; 2. Carbon tetrachloride (CCl4); 3. CCl4 + Cinnamon; 4. CCl4 + Ginger; 5. CCl4 + Cinnamon and Ginger; and 6. Cinnamon + Ginger. CCl4 (1 ml/kg) was injected intraperitoneally on the 14th day, and cinnamon (50 mg/kg, orally) and ginger (250 mg/kg, orally) were administered daily for 14 days. Fifty hours after the CCl4 injection, the testicles and epididymis were separated and examined as to histological alterations and oxidative stress markers. CCl4 significantly increased malondialdehyde level and decreased total antioxidant capacity when compared to the normal control group (p < .05). In addition, degenerative alterations in the testicular and epididymal tissue were observed in CCl4 group. The pre‐treatment with ginger and cinnamon extract significantly improved these parameters when compared to the CCl4 group (p < .05). The results of this study indicated that co‐treatment of ginger and cinnamon reduces the damages induced by CCl4 in testicular tissue by increasing antioxidant capacity and reducing lipid peroxidation.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :محمد مأذنی
نویسنده :معسود اوجارودی
نویسنده :شکوفه بنایی
نویسنده :رامین سلیم نژاد
نویسنده :میلاد لطیفی
نویسنده :هانیه عزیزی
نویسنده مسئول :لطف اله رضاقلی زاده
Additional Information:IF: 1.840 Indexed in: ISI, PubMed/Medline, Scopus, Embase
کلیدواژه ها (انگلیسی):CCl4 ,Cinnamon, Ginger, Oxidative Stress. Testis
Subjects:QU Biochemistry
QV pharmacology > QV 766 Plants, Medicinal
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Biochemistry
ID Code:13025
Deposited By: Dr Mohammad Mazani
Deposited On:08 Mar 1399 12:45
Last Modified:08 Mar 1399 12:45

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