title

اثرات قرارگیری در معرض محیط غنی شده در طول مدت نوجوانی بر یادگیری اجتنابی غیر فعال، درد و سطح BDNF پره فرونتال در موشهای صحرایی نر و ماده جوان

صادق زاده, فرشید and سخایی, نونا and عیسی زاده فر, خاطره and سعادتی, حکیمه (1399) اثرات قرارگیری در معرض محیط غنی شده در طول مدت نوجوانی بر یادگیری اجتنابی غیر فعال، درد و سطح BDNF پره فرونتال در موشهای صحرایی نر و ماده جوان. Neuroscience Letters ــ 732 (135133). pp. 133-135. شاپا 0304-3940

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Title

Effects of exposure to enriched environment during adolescence on passive avoidance memory, nociception, and prefrontal BDNF level in adult male and female rats

English Abstract

Previous studies demonstrated that an enriched environment (EE) exposure improves cognitive functions, synaptic plasticity, neurogenesis, and induction of brain-derived neurotrophic factor (BDNF) in multiple brain regions of laboratory animal models. Also, studies on the sex-dependent effects of exposure to EE during adolescence on adult cognitive functions are less. Therefore, the present experiment was aimed to assess the effects of EE during adolescence on passive avoidance learning and memory, nociception, and prefrontal cortex (PFC) BDNF mRNA levels in the adult male and female rats. Our results indicated that housing in the EE during adolescence improves passive avoidance memory and increases nociceptive response against thermal stimulus in both sexes. Findings of our study also showed an increased BDNF level in the PFC of female animals. As a result, sex differences can affect the expression of BDNF mRNA in the PFC. Further research concerning the precise mechanisms underlying sex hormone-dependent production of BDNF in PFC is critical. Previous article

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :فرشید صادق زاده
نویسنده :نونا سخایی
نویسنده :خاطره عیسی زاده فر
نویسنده مسئول :حکیمه سعادتی
Additional Information:IF:3.197 Indexed in: ISI, PubMed/Medline, Scopus, Embase
کلیدواژه ها (انگلیسی):Enriched environment,Gender differences,Passive avoidance memory,Nociception,BDN
Subjects:WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:13062
Deposited By: Dr. Hakimeh Saadati
Deposited On:26 Mar 1399 14:58
Last Modified:20 Dec 1402 11:12

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