پروتکل های جدید در درمان ترکیبی سرطان: مرگ سلولی ایمونوژنیک

اسدزاده, زهرا and صفرزاده, الهام and صفایی, سحر and برادران, علی and محمدی, علی and حاجی اصغرزاده, خلیل and درخشانی, افشین and Argentiero, Antonella and Silvestris, Nicola and برادران, بهزاد (1399) پروتکل های جدید در درمان ترکیبی سرطان: مرگ سلولی ایمونوژنیک. Cancers ــ 12 (4). p. 1047. شاپا 2072-6694

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Official URL: https://www.mdpi.com/2072-6694/12/4/1047


Current Approaches for Combination Therapy of Cancer: The Role of Immunogenic Cell Death

English Abstract

Cell death resistance is a key feature of tumor cells. One of the main anticancer therapies is increasing the susceptibility of cells to death. Cancer cells have developed a capability of tumor immune escape. Hence, restoring the immunogenicity of cancer cells can be suggested as an effective approach against cancer. Accumulating evidence proposes that several anticancer agents provoke the release of danger-associated molecular patterns (DAMPs) that are determinants of immunogenicity and stimulate immunogenic cell death (ICD). It has been suggested that ICD inducers are two different types according to their various activities. Here, we review the well-characterized DAMPs and focus on the different types of ICD inducers and recent combination therapies that can augment the immunogenicity of cancer cells.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :زهرا اسدزاده
نویسنده اول :الهام صفرزاده
نویسنده :سحر صفایی
نویسنده :علی برادران
نویسنده :علی محمدی
نویسنده :خلیل حاجی اصغرزاده
نویسنده :افشین درخشانی
نویسنده :Antonella Argentiero
نویسنده مسئول :Nicola Silvestris
نویسنده مسئول :بهزاد برادران
Additional Information:IF: 6.126 Indexed in: ISI, PubMed/Medline, Scopus, Embase, DOAJ
کلیدواژه ها (انگلیسی):immunogenic cell death; DAMPs; combination therapy
Subjects:QW Microbiology and Immunology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Immunology
ID Code:13115
Deposited By: Dr elham safarzadeh
Deposited On:10 Jul 1399 08:27
Last Modified:20 Jun 1400 13:29

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