کدام ژنوتایپ هلیکو باکتر پیلوری-cagA یاcagE با ریسک ابتلا به سرطان معده همراهی بهتری دارد-درسهایی از یک منطقه پر خطر باریسک بسیار بالا در ایران

عنوان انگليسی

Which genotype of Helicobacter pylori—cagA or cagE—Is better associated with gastric Cancer risk? Lessons from an extremely high-risk area in Iran

خلاصه انگلیسی

The association of the H. pylori cagA- /cagE-positive genotypes with the risk of gastric cancer (GC) in Ardabil—a high-risk area in North-West Iran—was assessed. Genotyping was performed in DNA from fresh gastric biopsies (N = 218). Occurrence of H. pylori infection was 85.32% (186/218). The total frequency of the cagA+vs. cagA−, cagE+vs. cagE−, cagA+/cagE−vs. AGCs (all genotype combinations), cagA−/cagE+vs. AGCs, cagA−/cagE−vs. AGCs, cagA+/cagE+vs. AGCs, cagA+/cagE−vs. cagA−/cagE+, and cagA+/cagE+vs. cagA−/cagE− genotypes was 102/186 (54.8%), 89/186 (47.8%), 38/186 (20.4%), 25/186 (13.4), 59/186 (31.7%), 64/186 (34.4%), 38/63 (38.63%), and 64/123 (52.0%), respectively. The cagE+vs. cagE− (59.6% (65/109) in GC vs. 31.2% (24/77) in non-atrophic gastritis, NAG) and the cagA+/cagE+vs. cagA−/cagE− genotypes (66.7% (40/60) in GC vs. 38.1% (24/63) in NAG) showed an increased association with the risk of GC in Ardabil (odds ratio [OR] = 3.262, 95% confidence interval [CI]: 1.763–6.038, p = .0001 and OR = 3.250; 95% CI: 1.552–6.808, p = .002, respectively). We propose that the H. pylori cagE+ but not cagA+ genotype significantly increased the risk of GC in this extremely high-risk population. Therefore, it may play a significant role in determining H. pylori-related clinical outcome

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