ظهور نقش نانومتریال های نقره در مبارزه با سرطان ریه: مطالعه مروری سیستماتیک

برآبادی, حامد and حسینی, امید and کمالی, کاوه and جزایری شوشتری, فرشته and رشیدی, معصومه and حقی امین جان, حامد and متوپاندیان, سراوانان (1398) ظهور نقش نانومتریال های نقره در مبارزه با سرطان ریه: مطالعه مروری سیستماتیک. Journal of Cluster Science ــ 31 (1). شاپا 1572-8862

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Official URL: https://link.springer.com/article/10.1007/s10876-0...


Emerging Theranostic Silver Nanomaterials to Combat Lung Cancer: A Systematic Review

English Abstract

Lung cancer remains the leading cause of one-quarter of all cancer deaths and it’s a major public health problem worldwide. Nanotechnology offers a novel strategy to combat lung cancer. Recently, biologically synthesized silver nanoparticles (AgNPs) has attracted significant attention for their anticancer effects against lung cancer. Thereby, the current study was aimed to systematically review the efficacy of these nanoparticles (NPs) against lung cancer through in vitro models. The articles were collected through online databases comprising Cochrane, Web of Science, PubMed, Scopus, Science Direct, ProQuest, and Embase. Among all studies, the plant-mediated synthesis of AgNPs was the general approach. Besides, A549 lung cancer cell line was the predominant cell line that was applied for cytotoxicity assessment among all studies. Most of the AgNPs were synthesized with spherical morphology less than 100 nm. Interestingly, in almost all of the studies, AgNPs exhibited the half maximal inhibitory concentration (IC50) against lung cancer cells. We provided preliminary evidence indicating the significant anticancer activity of biogenic AgNPs. We also discussed the proposed anticancer mechanisms. However, further studies are required to evaluate the anticancer efficacy of biogenic AgNPs through in vivo models.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :حامد برآبادی
نویسنده :امید حسینی
نویسنده :کاوه کمالی
نویسنده :فرشته جزایری شوشتری
نویسنده مسئول :معصومه رشیدی
نویسنده :حامد حقی امین جان
نویسنده مسئول :سراوانان متوپاندیان
Additional Information:IF: 2.125 Indexed in: ISI, Scopus
کلیدواژه ها (انگلیسی):Lung cancer, Cancer nanomedicine, Biological synthesis, Silver nanoparticles
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology > QV 737 Pharmaceutical Biotechnology
QV pharmacology > QV 704 Pharmaceutics
QV pharmacology
Divisions:Vice Chancellor for Research and Technology > Pharmaceutical Sciences Research Center
ID Code:13195
Deposited By: Dr Hamed Haghi-Aminjan
Deposited On:30 Apr 1399 09:22
Last Modified:30 Apr 1399 09:22

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