title

مکانیسم محافظتی کانابیدیول در آسیب قلبی: یک مطالعه مروری سیستماتیک از مطالعات غیر بالینی

هوشنگی شایسته, محمدرضا ، حقی امین جان, حامد ، موسوی, محمد جواد ، ممتاز, سعیده ، عبداللهی, محمد (1398) مکانیسم محافظتی کانابیدیول در آسیب قلبی: یک مطالعه مروری سیستماتیک از مطالعات غیر بالینی. Current Pharmaceutical Design ــ 25 (22). ص.ص.2499-2507. شاپا 1873-4286

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آدرس اینترنتی رسمی : https://www.eurekaselect.com/173374/article


عنوان انگليسی

The Protective Mechanism of Cannabidiol in Cardiac Injury: A Systematic Review of Non-Clinical Studies

خلاصه انگلیسی

Background: Cardiac disease is accounted as the leading cause of worldwide morbidity and mortality. The disease is characterized by the overproduction of reactive oxygen and/or nitrogen species (ROS/RNS), and induction of oxidative stress. Cannabidiol (CBD) is a non-psychoactive ingredient of marijuana that has been reported to be safe and well tolerated in patients. Due to its pleiotropic effect, CBD has been shown to exert cytoprotective effects. This study intended to clarify the mechanisms and the potential role of CBD regarding cardiac injuries treatment. Methods: A systematic literature search was conducted, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, in the electronic databases including PubMed, Web of Science, Scopus, and Embase up to June 2019 using predefined search terms in the titles and abstracts. Accordingly, a set of pre-specified inclusion and exclusion criteria were considered and 8 articles were ultimately included in this study. Results: Our findings demonstrate that CBD has multi-functional protective assets to improve cardiac injuries; preliminary through scavenging of free radicals, and reduction of oxidative stress, apoptosis, and inflammation. Conclusion: CBD can protect against cardiac injuries, mainly through its antioxidative and antiapoptotic effects on the basis of non-clinical studies. The cardioprotective effects of the CBD need to be further studied in well designed clinical trials. Keywords: Cannabinoids; cardiac injury; cardioprotective effects; free radicals; oxidative stress; systematic review.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :محمدرضا هوشنگی شایسته
نویسنده :حامد حقی امین جان
نویسنده :محمد جواد موسوی
نویسنده :سعیده ممتاز
نویسنده مسئول :محمد عبداللهی
ضریب تاثیر و نمایه مجلات:IF: 2.412 Indexed in: ISI, Scopus, PubMed/Medline, Embase
کلیدواژه ها (انگلیسی):Cannabinoids; cardiac injury; cardioprotective effects; free radicals; oxidative stress; systematic review
موضوعات :QV فارماکولوژی > QV 600 سم شناسی
بخش های دانشگاهی :معاونت تحقیقات و فناوری > مرکز تحقیقاتی علوم دارویی
کد شناسایی :13200
ارائه شده توسط : دکتر حامد حقی امین جان
ارائه شده در تاریخ :01 مرداد 1399 10:07
آخرین تغییر :01 مرداد 1399 10:07

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