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نقش التهاب مزمن به عنوان پیش گویی کننده مرحله و درجه کانسر پروستات: یافتن گروه جدید مناسب جهت Active Surveillance

نوروزی, محمدرضا ، آیتی, محسن ، امینی, عرفان ، سیدمجید, آقامیری ، سیدعلی, معینی ، سولماز, اوحدیان مقدم ، ولی زاده, فرزین (1399) نقش التهاب مزمن به عنوان پیش گویی کننده مرحله و درجه کانسر پروستات: یافتن گروه جدید مناسب جهت Active Surveillance. Urology Journal ــ 17 (4). ص.ص.370-373. شاپا 1735-1308

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عنوان انگليسی

Role of Chronic Inflammation as a Predictor of Upstaging/Upgrading in Prostate Cancer: Finding a New Group Eligible for Active Surveillance

خلاصه انگلیسی

PURPOSE: We aimed to investigate the correlation between presence of inflammation and pathology upgrading/upstaging in patients with prostate cancer. MATERIALS AND METHODS: A retrospective study was accomplished on 315 patients with prostate cancer, eligible for active surveillance except prostate-specific antigen (PSA) level (PSA<30ng/dL), who underwent radical prostatectomy between 2005 and 2015. Patients were divided into two groups based on needle biopsy: A; with evidence of inflammation (chronic prostatitis) and B; without inflammation. The frequency of upstaging and upgrading in both groups was compared in different ranges of PSA level (<10, 10-20 and 20-30ng/dL). Upgrading/Upstaging was defined as increase from one prognostic grade group to another. Statistical analyses were performed to investigate the relation between inflammation and upgrading/upstaging. RESULTS: The mean age of the patients was 68.2 years and the mean PSA level was 10.2 ng/mL. Chronic prostatitis was identified in 82 of 315 cases therefore upgrading/upstaging were seen in only three patients (3.7%) while 39 of 233 (16.7%) patients without inflammation had upgrading/upstaging in final pathology (P = 0.003). Other variables including the patient's PSA before surgery, PSA density, and the presence of hypoechoic areas in ultrasound had a significant relationship with the incidence of postoperative upgrading/upstaging. Among studied variables, presence of inflammation in biopsies was found to be the most important predictor of upstaging/upgrading (OR: 0.205). CONCLUSION: Our data demonstrated that patients with concurrent prostatitis and PCa may have a better prognosis even if the PSA level is higher than 10ng/mL.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :محمدرضا نوروزی
نویسنده :محسن آیتی
نویسنده :عرفان امینی
نویسنده :آقامیری سیدمجید
نویسنده :معینی سیدعلی
نویسنده :اوحدیان مقدم سولماز
نویسنده مسئول :فرزین ولی زاده
ضریب تاثیر و نمایه مجلات:IF: 1.378 Indexed in: ISI, Scopus, PubMed/Medline
کلیدواژه ها (انگلیسی):prostate cancer; chronic prostatitis; serum PSA; active surveillance
موضوعات :WJ سیستم ادراری
بخش های دانشگاهی :دانشكده پزشكي > گروه جراحی
کد شناسایی :13256
ارائه شده توسط : خانم صغری گلمغانی
ارائه شده در تاریخ :16 مرداد 1399 09:12
آخرین تغییر :16 مرداد 1399 09:12

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