نقش التهاب مزمن به عنوان پیش گویی کننده مرحله و درجه کانسر پروستات: یافتن گروه جدید مناسب جهت Active Surveillance

نوروزی, محمدرضا and آیتی, محسن and امینی, عرفان and سیدمجید, آقامیری and سیدعلی, معینی and سولماز, اوحدیان مقدم and ولی زاده, فرزین (1399) نقش التهاب مزمن به عنوان پیش گویی کننده مرحله و درجه کانسر پروستات: یافتن گروه جدید مناسب جهت Active Surveillance. Urology Journal ــ 17 (4). pp. 370-373. شاپا 1735-1308

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Official URL: https://journals.sbmu.ac.ir/urolj/index.php/uj/art...


Role of Chronic Inflammation as a Predictor of Upstaging/Upgrading in Prostate Cancer: Finding a New Group Eligible for Active Surveillance

English Abstract

PURPOSE: We aimed to investigate the correlation between presence of inflammation and pathology upgrading/upstaging in patients with prostate cancer. MATERIALS AND METHODS: A retrospective study was accomplished on 315 patients with prostate cancer, eligible for active surveillance except prostate-specific antigen (PSA) level (PSA<30ng/dL), who underwent radical prostatectomy between 2005 and 2015. Patients were divided into two groups based on needle biopsy: A; with evidence of inflammation (chronic prostatitis) and B; without inflammation. The frequency of upstaging and upgrading in both groups was compared in different ranges of PSA level (<10, 10-20 and 20-30ng/dL). Upgrading/Upstaging was defined as increase from one prognostic grade group to another. Statistical analyses were performed to investigate the relation between inflammation and upgrading/upstaging. RESULTS: The mean age of the patients was 68.2 years and the mean PSA level was 10.2 ng/mL. Chronic prostatitis was identified in 82 of 315 cases therefore upgrading/upstaging were seen in only three patients (3.7%) while 39 of 233 (16.7%) patients without inflammation had upgrading/upstaging in final pathology (P = 0.003). Other variables including the patient's PSA before surgery, PSA density, and the presence of hypoechoic areas in ultrasound had a significant relationship with the incidence of postoperative upgrading/upstaging. Among studied variables, presence of inflammation in biopsies was found to be the most important predictor of upstaging/upgrading (OR: 0.205). CONCLUSION: Our data demonstrated that patients with concurrent prostatitis and PCa may have a better prognosis even if the PSA level is higher than 10ng/mL.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :محمدرضا نوروزی
نویسنده :محسن آیتی
نویسنده :عرفان امینی
نویسنده :آقامیری سیدمجید
نویسنده :معینی سیدعلی
نویسنده :اوحدیان مقدم سولماز
نویسنده مسئول :فرزین ولی زاده
Additional Information:IF: 1.378 Indexed in: ISI, Scopus, PubMed/Medline
کلیدواژه ها (انگلیسی):prostate cancer; chronic prostatitis; serum PSA; active surveillance
Subjects:WJ Urogenital System
Divisions:Faculty of Medicine > Department of Surgery
ID Code:13256
Deposited By: MS Soghra Golmaghani
Deposited On:16 May 1399 09:12
Last Modified:16 May 1399 09:12

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