title

روش های ایمونوتراپی جهت مقابله با کووید-19

اوجی, هاجر and نگهداری پور, مانیکا and حاجی قهرمانی, نسیم (1399) روش های ایمونوتراپی جهت مقابله با کووید-19. International Immunopharmacology ــ 88 (2020). p. 106924. شاپا 15675769

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Title

Immunotherapeutic approaches to curtail COVID-19

English Abstract

COVID-19, the disease induced by the recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has imposed an unpredictable burden on the world. Drug repurposing has been employed to rapidly find a cure; but despite great efforts, no drug or vaccine is presently available for treating or prevention of COVID-19. Apart from antivirals, immunotherapeutic strategies are suggested considering the role of the immune response as the host defense against the virus, and the fact that SARS-CoV-2 suppresses interferon induction as an immune evasion strategy. Active immunization through vaccines, interferon administration, passive immunotherapy by convalescent plasma or synthesized monoclonal and polyclonal antibodies, as well as immunomodulatory drugs, are different immunotherapeutic approaches that will be mentioned in this review. The focus would be on passive immunotherapeutic interventions. Interferons might be helpful in some stages. Vaccine development has been followed with unprecedented speed. Some of these vaccines have been advanced to human clinical trials. Convalescent plasma therapy is already practiced in many countries to help save the lives of severely ill patients. Different antibodies that target various steps of SARS-CoV-2 pathogenesis or the associated immune responses are also proposed. For treating the cytokine storm induced at a late stage of the disease in some patients, immune modulation through JAK inhibitors, corticosteroids, and some other cognate classes are evaluated. Given the changing pattern of cytokine induction and immune responses throughout the COVID-19 disease course, different adapted approaches are needed to help patients. Gaining more knowledge about the detailed pathogenesis of SARS-CoV-2, its interplay with the immune system, and viral-mediated responses are crucial to identify efficient preventive and therapeutic approaches. A systemic approach seems essential in this regard.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :هاجر اوجی
نویسنده مسئول :مانیکا نگهداری پور
نویسنده :نسیم حاجی قهرمانی
Additional Information:Impact Factor: 3.943 Indexing in: ISI, Scopus, PubMed/Medline, Embase
کلیدواژه ها (انگلیسی):COVID-19,Pandemic,Severe acute respiratory syndrome coronavirus 2, Antibodies, Plasma therapy, Immunotherapy
Subjects:QV pharmacology > QV 737 Pharmaceutical Biotechnology
Divisions:School of Pharmacy > Department of Pharmaceutical Biotechnology
ID Code:13351
Deposited By: Dr Nasim Hajighahramani
Deposited On:15 Jun 1399 12:36
Last Modified:15 Jun 1399 12:36

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